ID H2LCH3_ORYLA Unreviewed; 713 AA.
AC H2LCH3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Solute carrier family 23 member 2 {ECO:0000313|Ensembl:ENSORLP00000003610.2};
GN Name=SLC23A2 {ECO:0000313|Ensembl:ENSORLP00000003610.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003610.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003610.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003610.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003610.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003610.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR RefSeq; XP_011477209.1; XM_011478907.1.
DR AlphaFoldDB; H2LCH3; -.
DR STRING; 8090.ENSORLP00000003610; -.
DR Ensembl; ENSORLT00000003611.2; ENSORLP00000003610.2; ENSORLG00000002889.2.
DR GeneID; 101156743; -.
DR CTD; 9962; -.
DR eggNOG; KOG1292; Eukaryota.
DR GeneTree; ENSGT00950000182953; -.
DR HOGENOM; CLU_017959_5_4_1; -.
DR InParanoid; H2LCH3; -.
DR OrthoDB; 911690at2759; -.
DR TreeFam; TF313272; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000002889; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0019852; P:L-ascorbic acid metabolic process; IBA:GO_Central.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR PANTHER; PTHR11119:SF33; SOLUTE CARRIER FAMILY 23 MEMBER 2; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 152..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 35..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 77039 MW; 13BBE6DB57ADF598 CRC64;
MLPAAPLDRS DGMCQLDDAL LDNVIGLRDS SAVCSLEEDT GGTEEEEGKD CEDARMGVGK
NTSKSLDSSS DGGKYEDDRK HGVDFYPIPV VVNGVGGASG DQDTENTELM SIYTKDNQGA
EKSSMSETLD STGSTDARRM DMIYTIEDTP PWYLCVFLGL QHYLTCFSGT IAVPFLLAEA
MCVGSDQWAT SQLIGTIFFC VGITTLLQTT FGCRLPLFQA SAFAFLAPAK AILSLDKWKC
NNTEFPGLNG TELLHTEHIW HPRIREIQGA IIVSCLIEVC IGLLGLPGML LKYIGPLTIT
PTVALIGLSG FQAAGERAGK HWGIAMLTIF LVLLFSQYAR NVHFPLPIYK AKKGWTSYRL
QVFKMFPIIM AILVSWLLCF IFTVTDVFPP EKDKYGFYAR TDARQGILTA APWFKVPYPL
QWGMPTVTAA GVIGMMSAVV ASIIESIGDY YACARLSCAP PPPIHAINRG IFVEGISCVL
DGLFGTGNGS TSSSPNIGVL GITKVGSRRV IQYGAAMMLL LGLVGKFSAL FASLPDPVLG
ALFCTLFGMI TAVGLSNLQF VDLNSSRNLF VLGFSIFFGL MLPSYLKQNP LVTGIVEIDQ
VLNVLLTTAM FVGGSVAFIL DNTIPGSLEE RGIRKLKRGS GLSAAELEGM NSYDLPFGMD
FIRRHSIFKH IPISPTFTGY HWGRRKDSIK SRKGHGDAVK GGEGGSASGE SGV
//
