ID H2LD63_ORYLA Unreviewed; 1644 AA.
AC H2LD63;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Transcription elongation factor spt6 {ECO:0000256|PIRNR:PIRNR036947};
GN Name=supt6h {ECO:0000313|Ensembl:ENSORLP00000003862.3};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003862.3, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003862.3, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003862.3,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003862.3}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003862.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription elongation factor that enhances transcription
CC elongation by RNA polymerase II (RNAPII).
CC {ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000256|ARBA:ARBA00009253,
CC ECO:0000256|PIRNR:PIRNR036947}.
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DR Ensembl; ENSORLT00000003863.3; ENSORLP00000003862.3; ENSORLG00000003098.3.
DR eggNOG; KOG1856; Eukaryota.
DR GeneTree; ENSGT00510000047446; -.
DR HOGENOM; CLU_001680_4_0_1; -.
DR TreeFam; TF105956; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000003098; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd00164; S1_like; 1.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF00575; S1; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 2.
DR SMART; SM00316; S1; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036947};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036947};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR036947}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 87..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1150..1205
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1248..1338
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 27..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1603..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 405..436
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1541..1571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1644 AA; 188942 MW; 94C92B1DD10CD78D CRC64;
MVRNEVVFFF PNWSTRTCSP RTCQFKTDEE EDVDNPEEQD EHGNLRGLID DGDDDGEEEE
EAPKSGSGGG SDSEEEVRHR RKKRSKFSIF LCFFFFSPCV CDTCGNYSWV SLLFMFSNTF
TIRLNFLYFP QKKGTFFNMC FKSSFSRALQ EAQEIFGGDF DFADIGVDEG GEEEEEDPEE
EGWDRPKKQT KRRLGRKSIF EIYEPSELES SHMTDQDNEI RSTDMPERFQ LRSIPVKPAE
DDELEEEAEW IFRHGFSTLT ISMQESTDYL DRGTTTNFSR KGPSTIAKIK EALNFMRNQQ
FEVPFIAFYR KEYVEPELNI NDLWKVWQWD EKWTQLRTRK QNLTRLFQKM QSYQFEQISA
DPDKPLADGV RPLDTADMER LKDVQTLEEL GDVYNHFLLY YGRDIPKMQN AAKSTKKRLK
KIREEELEIE EEEEQKAPDL KQASRRDMYS ICQSVGLDGL AKKFGLTPEQ FGENLRDSYQ
RHETEQFPAE PLELAKDYVC SQFSTPENVL VGTRYMVAMQ IAREPLVRHV LRQTFQERAK
INIKPTKKGK KEVDEAHFAY SFKYLKNKPV KELNGDQFLK MCLAEEEGLL TIDICIDLIG
VKGYAGDQTY FDEIKQFYYR DEFSHQVQEW NRQRTLAIER ALNQFLYPQM AKELKSKLIA
EAKENISCCR RLYNWLKVAP YRPDQQVEED DDLMDESQGK GIRVLGVAYA PSRDTPVFCA
LINGEGEVVD FLRLPYFMKR RNAFREDERE KKANDIENLK KFLSSKKPHV VAVAGENRDA
QMIMEDIKRT ISELEQESSL SPVGVELVDN ELATLYMNSK KSENDFRDYP PLLRQAVSIA
RKIQDPLLEY AQVCSTDEDI LCLKLHPLQE HVVKEDLLSA LYCEFINRVN EVGVDVNRAI
AHPHTQSLVQ YVCGLGSRKG SHLLKILKQN NTRLENRTQL VTMCHMGPKV FINCAGFIKI
DTASLGDSTD SYIEVLDGSR VHPETYEWAR KMAVDALEYD ESAEDANPAG ALEEILENPE
RLKDLDLDAF AEELERQGYG NKGITLYDIR AELSCRYKDL RVLYRVPNTE EVFNMLTKET
PETFYIGKLI TSIVTGIAHR RPQGESYDQA IRNDATGLWQ CPFCQQDNFP ELSEVWNHFD
SGSCPGQAIG VRSRLDNGVQ GFIPTKFLSD KVVKHPEERV KVGMTVHCRI MKIDIEKFSV
DLTCRTSDLM DKNNEWKLPK DTYYDFDTEA EDQKHDEELK KKQQRTPYIK RVIAHPNFHN
ISFNQAEKMM ETLDQGDLII RPSSKGENHL TVTWKVADGI YQHVDVREEG KENAFSLGHT
LWINNEEFED LDEIIARYIQ PMASFARDLL GHKYFQDCNG GSREKMEEAL IKTKREKPTF
IPYFISACKD LPGKFILGYQ PRGKPRIEYV TITPDGFRYR SQIFPTVNGL FRWFKDHYQE
PVPGVTPSNS SRTRTPASLN ATPANINIAD LTRAVNALPR NMTSQMFSAI AAVTGQGQNP
NTTPAQWGSS QYGYGGSTGG GGSSSAYHVF ATPQQPIATP MMTPSYSYTT PSQQALGTPQ
YPGSTPQSSH AHHQHLPHHS HAPHSSHHAV DWGKMAEQWL KEKEAEGRKK ATRMTPRPSP
SPMIESTPMS ITGDATPLLD EMDR
//
