ID H2LKP7_ORYLA Unreviewed; 688 AA.
AC H2LKP7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Collagen, type VIII, alpha 2 {ECO:0000313|Ensembl:ENSORLP00000006601.2};
GN Name=col8a2 {ECO:0000313|Ensembl:ENSORLP00000006601.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000006601.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000006601.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006601.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000006601.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006601.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004073917.2; XM_004073869.2.
DR AlphaFoldDB; H2LKP7; -.
DR STRING; 8090.ENSORLP00000006601; -.
DR Ensembl; ENSORLT00000006602.2; ENSORLP00000006601.2; ENSORLG00000005237.2.
DR eggNOG; ENOG502QRST; Eukaryota.
DR GeneTree; ENSGT00940000154317; -.
DR HOGENOM; CLU_001074_21_0_1; -.
DR InParanoid; H2LKP7; -.
DR OrthoDB; 4267525at2759; -.
DR TreeFam; TF334029; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000005237; Expressed in pharyngeal gill and 6 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF33; EMI DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 4.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..688
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017272127"
FT DOMAIN 555..688
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 58..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..233
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..523
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 67320 MW; B3628318D71F3BE8 CRC64;
MLVTMMLASV CFLLTFGARA LAGGYPPMPH MKYMQPMMKG PIGPPFREGK GHYVDMPPMM
EVKGEPGPQG KPGPRGPPGP PGLPGKPGLG KQGLNGQPGP QGPPGLPGIG KPGLPGLPGK
IGPRGIPGLN GEVGPHGEPG PRGPPGQPGL PGPVGLSLNG KPGLPGIRGP PGARGEPGIS
GVPGPPGERG LKGENGNGKP GLPGIIGPPG LKGIRGPPGP PGLGKPGPNG VPGLPGPKGD
NGLPGDQGKP GEPGAPGLQG LPGPVGLGKP GLDGLPGVTG PLGAKGEPGP RGSPGAPGTP
GYGKPGVTGP KGEKGHGGFP GLKGDRGEQG MVGPTGGPGI DGLPGPPGLQ GPMGLPGKHG
LSGQKGELGP QGPPGLPGFR GDQGSMGPPG KPGIPGEKGF PGPSGSIGKP GPKGDAGNVG
LPGNPGMSGA QGPKGEPGFI GTPGPRGQSG IPGLQGPMGP MGPQGVPGLR GEPGLPGPPG
LGKLGEKGAI GPQGPPGKPG PTGLNGNPGP PGPPGPPGPP GNGQTVVAGP TGTGLGGEEV
PGDRKVPAFI QVPLSSSVAP AFTAILTTPF PPSSMPIKFD RILYNGQNAY SPSTGIFTAP
LSGVYYFAYH MHVKGTSLWV ALYKNNVPAT YTYDEYKKGY MDQASGSAVL ELKEGDQVWV
QMPSDQANGL YSTEYIHSSF SGFLLCPT
//
