ID H2LN50_ORYLA Unreviewed; 902 AA.
AC H2LN50;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Neutral sphingomyelinase activation associated factor {ECO:0000313|Ensembl:ENSORLP00000007475.2};
GN Name=NSMAF {ECO:0000313|Ensembl:ENSORLP00000007475.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007475.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007475.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007475.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007475.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007475.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LN50; -.
DR Ensembl; ENSORLT00000007476.2; ENSORLP00000007475.2; ENSORLG00000005939.2.
DR eggNOG; KOG1786; Eukaryota.
DR GeneTree; ENSGT00940000155059; -.
DR HOGENOM; CLU_000218_5_2_1; -.
DR TreeFam; TF324912; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000005939; Expressed in blastula and 14 other cell types or tissues.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 171..268
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 272..557
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 696..735
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 744..785
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 786..827
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 867..902
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 562..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 102109 MW; D0E4C63C1A21D1CB CRC64;
MVHRFSLLLL DLEEYFFEQH TAHHVVPNGS KKDKKVRGSF KVCSRSIIFD PEDFVEPILK
IPLRDCTNIE FVERETNPFN EPRPAAVCVS CEQVIFIKEV NVIEAYRNER GSKKMTFQLE
VQSKTEDVVQ TLLQLHRASC LEKLGDQTAM IAANLQSRLA RSSFDKNCFQ SVAEKPHMEC
TVEMVTPLVS NPGHVCITDE NLYFQPLNGY PEQVIQIKLQ QVRRIYKRRH GLKPLGLEVF
CTENDLCSDI YLKFYNTADR DEIYYYMATF LENHITEHTA ESYMLQWQRG HISNYQYLLH
LNNLADRSCN DLSQYPVFPW VIADYGSSQL DLTNAATFRD LSKPVGALNK ERLDRLLARY
SGMPEPRFIY GSHYSSPGYV LFYLVRVAPE HMLCLQNGRY DHPDRMFNCI AETWKNCLEG
ATDFKELIPE FYGSDSSFLE NRLNLDLGRR QNGSLVGDVS LPPWASDASD FLEKHKAALE
SPFVSEHLHE WIDLVFGFKQ RGSDAEAAHN VFHPLTYEGN IDCDSIEDTD QRIAMLTQIL
EFGQTPKQLF NSPHPQRITA KFQSTRRSSS ITSPVGELSP ASPCEDSSFE DLTDESRKLA
WANMGSLKAS SSCRMHKEAV TGIAVTRDGA SLFSTSLDST LKMFSKEMDF QRSMSFSNMP
LSSCLVLADG KTVACSSWDN NVYFYSVPYG RRQDTLMGHD DAVSEMCWFE NRLYTASWDS
TVKVWQLDSN DSSVKRSRFD LLAELEHDDG VNTVGLNAAG TLLGSGCKDG TLTIWDTSSF
EVFQQVQCHT GNIHHLAFSP DSRHILSVGS DSCMKMTDVQ TGMVISAVKA EEEQRCFCWD
GSSALCGGQS GDLILWDLLS NTVTTKIPAH SGAVTAMWMN ELGNTVITGG EDRQMFFWKV
QS
//
