ID H2LP43_ORYLA Unreviewed; 1163 AA.
AC H2LP43;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase {ECO:0000313|Ensembl:ENSORLP00000007823.2};
GN Name=cilp {ECO:0000313|Ensembl:ENSORLP00000007823.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007823.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007823.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007823.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007823.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007823.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_004067079.1; XM_004067031.2.
DR AlphaFoldDB; H2LP43; -.
DR Ensembl; ENSORLT00000007824.2; ENSORLP00000007823.2; ENSORLG00000006227.2.
DR GeneID; 101166038; -.
DR KEGG; ola:101166038; -.
DR CTD; 8483; -.
DR eggNOG; ENOG502QQ8H; Eukaryota.
DR GeneTree; ENSGT00390000008152; -.
DR HOGENOM; CLU_008073_0_0_1; -.
DR InParanoid; H2LP43; -.
DR OrthoDB; 5383253at2759; -.
DR TreeFam; TF330132; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000006227; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR039675; CILP1/CILP2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR15031:SF5; CARTILAGE INTERMEDIATE LAYER PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR15031; CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13330; Mucin2_WxxW; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 279..377
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1130..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1155
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 130064 MW; 8B561E35E0E0036C CRC64;
MWVKREIMPQ RPLVFLAITA AVVLTAQGSW RRDNKASDVY HSNDHYMWTT WFNVDHPGGR
GDYEQLDAIR FYYRSRVCET PRAVEARTTE WIPARETGEI VHADPSVGFW CLNTEQSPGR
NCSNYAVRFL CPKDSSQTTQ GTWGPWSNWS PCPALCGQEA MQRRYRSCRS QLVPCSGPKT
EEKPCNGPEC INADCSLRCV MGRVNADCDA CMCEEHILLG SVRSAGGLIA TGAAILRANK
LLTLTDHNGH FRIPGICPDG NTTLTVNVKG HASLNAVVPS STERTSVLTI QLKRAEKLHI
LSNPESKARR EGQSVAFCCK VAGRPEPDKY QWFHNNTVME METDGMLVLR DLHSQQAGEY
YCRASGASGT IKSKPATLKV IGKDERSCNP KPESHLIRLP HDCHQNTTDS FYYDVGKCPS
SQCTGQIDNS IRCKDKLAYC CGVAKMEERQ LTCQGYQLPT MVVTECGCKK CVDTKAVVHG
RAIAADNGEP MRFGHIFMNG VRVSRTGYKG TFSIQVPPDT DRFVLTFVDN MQKFVNTTKV
LPFNTKGGAV YHEVKLLRKK NPVTISSLET NTLELGEVKD QEAMVQIQIP PHSFYKENGE
VFTGNVSASV TFLDPRDVST AAAAQSDLNF IGNEGDTLPL RTYGMFSIDF RAEENNEVLN
AGEVKVFLDS AQVKMSEHLD AMKLWSLNPD TGLWEEEGDL KIERKNRGKR EERTFLIGNM
EIRERRLFNL DVPENRRCYV KVRAFRGERF MPSEQVEGVT VSLINMEPTA GYSSNPRAWG
RFDSVITGSN GACLPAFCDE QKPDAYTAFV MANLGGEELE VVPSAPKFNP SLIGVPQPYL
GKLNYRRTDH EDPRVKKTAF SINVAKPSPN TAEEANGPVY TFENLKECEE APFSAGHFRF
SRVEGDRYDY NTVPFNEDDP MSWTEDYLSW WPKPMEYRAC YIKIKINSPH EINVRSRNMG
GTHPKTVGQL YGLRDTRSIR DMDLANVSAV CLEFKCSGML FDQDRVDRTL VKVIPQGSCR
RDGVNTMLQE YLVNHLPLAV NNDTNEFTML GPLDPLGHNY GIYTVTDQDP RTAKEIALGR
CFDGTSDGTS RVMKTNEGVA LTFTCGDRDG TRQSVFQASR GQIGAVVRGK TRNTRGRHRA
NSSRGIPKRS ARNPVRKLAK ATS
//