ID H2LPF5_ORYLA Unreviewed; 388 AA.
AC H2LPF5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Caspase a {ECO:0008006|Google:ProtNLM};
GN Name=LOC101174762 {ECO:0000313|Ensembl:ENSORLP00000007938.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007938.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007938.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007938.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007938.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007938.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_004075421.1; XM_004075373.2.
DR AlphaFoldDB; H2LPF5; -.
DR STRING; 8090.ENSORLP00000007938; -.
DR Ensembl; ENSORLT00000007939.2; ENSORLP00000007938.2; ENSORLG00000006320.2.
DR GeneID; 101174762; -.
DR KEGG; ola:101174762; -.
DR eggNOG; KOG3573; Eukaryota.
DR GeneTree; ENSGT00940000162428; -.
DR HOGENOM; CLU_036904_0_1_1; -.
DR InParanoid; H2LPF5; -.
DR OrthoDB; 2873736at2759; -.
DR TreeFam; TF102023; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000006320; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IBA:GO_Central.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd08325; CARD_CASP1-like; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR47901:SF6; CASPASE-12; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 2.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1..89
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 133..264
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 293..380
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 388 AA; 44180 MW; 1CDBE44ABFE91677 CRC64;
MAEELFKVRL KFVDKVSKPV LTQLLDMLLQ DKVLNDEERE SICEEKSRAD MARSLIDTVR
KKGSTASKMM INHFEQKDPI LFSELGLSCP EPAQTNSHSQ RDEPATTVLT AEDFWKKTQN
DPNVYPVTKA SYKSRVALMI TNIKFSNEKL NRAGAEKDEE NMDRLLSKLG YEVVKHKSLT
GKAINEAFIE FTKHPKLKET DSVIVVLMSH GKLGAVLGVE WKHDDENPDE FPVNSIYEHL
GPEKCPALLD KPKIIIIQAC RGDQTGSVCI SDSGNQAEEF LHPAAAGDLL EDNLRFVHKE
KDFISLLSCT PDTKAFRCRA RGSHLIQYIV EIFNTDADTL YIQELFRKVM LRFESFAFKH
NRQMATIERC TLLKQFYFYP GLGDTNHS
//
