ID H2LSE0_ORYLA Unreviewed; 2054 AA.
AC H2LSE0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=DS cell adhesion molecule like 1 {ECO:0000313|Ensembl:ENSORLP00000009001.2};
GN Name=DSCAML1 {ECO:0000313|Ensembl:ENSORLP00000009001.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009001.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009001.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009001.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009001.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009001.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000256|ARBA:ARBA00034103}.
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DR STRING; 8090.ENSORLP00000009001; -.
DR Ensembl; ENSORLT00000009002.2; ENSORLP00000009001.2; ENSORLG00000007177.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155354; -.
DR HOGENOM; CLU_001038_0_1_1; -.
DR InParanoid; H2LSE0; -.
DR TreeFam; TF316846; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000007177; Expressed in gastrula and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05734; Ig_DSCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF72; DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1587..1607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..205
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 214..294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 302..387
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 396..490
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 495..575
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 585..674
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 679..777
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 781..880
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 882..979
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 984..1083
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1088..1184
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1188..1283
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1284..1362
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1378..1472
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1477..1569
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1710..1733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1775..1798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1835..1859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1944..1969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2054 AA; 225087 MW; 742DACE003086354 CRC64;
MWLLVEDVVS TRLYFVNASL QRVTFSSSVG VSLPCPAGGA PHAVLRWYLA TGDDIYDVPH
IRHVHANGTL QLYPFSPSAY NSIIHDNEYF CTAENQAGKI RSPSIHIKAV FREPYTVRVA
DQRSMRGNVA VFKCLIPSAV QEYVSVVSWE KDTVSIVPGN RFFLTLYGAL YISEVQKEDA
LSTYRCITKH KYSGETRQSN GARLSVMDPT ESTPSVLDSF QSGEVQIGHN VELPCIASGY
PNPTIRWLKD GRPLPADSRW TRRITGLTIS DLRLEDSGNY ICEVTNSFGS KEVAGHLNVI
EPLRVTLSPK NLKTGISSTV ILSCAVQGSP HFTVSWYRNT ESVLPDQHFS IQGAHNETLF
ISAAQKRHSG AYQCFATRKG QTAQDFSIIL LEDGTPRIVA SFSERVVVPG EPFSLMCAAK
GAPPPTITWT LDDEPVARDL SRVRTSQYTL SDGSTVSHVN VSSPQIRDGG VYRCAARNSA
GSAEYQARIN VRGPPRIRPM KNITAVAGRN TFINCRVIGY PYYSINWYKD GLLLPDNHRQ
VVFENGTLKL SDVQKGMDEG AYVCSVLIQP QLFITQTVYV TVKVPPLIQP FDFPPTSIGK
LMYIACVVSS GDMPIHITWR KDGQEIVPSS GITIDTKEFM SSLQISKVSL KHNGNYTCIA
RNDAATVSTE RQLTVTVPPR FVVQPNNQDG IYGKAAILNC SVDGYPPPKV MWKHAKGALA
GIGNPQQYHP VPLTGRIQIM NNGSLLIRHV LEEDRGFYLC QASNGVGSDI SKSMVLTVKI
PAMITSHPNT TMAKKGHVKE LNCTARGEWP IIIRWERGDT VIDPDRNPRY SITTSPNEKT
DEVLSTLKLK PAEREDSVFF SCHAINSYGE GRGLIQLTVQ EPPDPPELEV REVKDRSMNL
RWTQRFDGNS IITSYDIEYK NKTDTWELKH ATRNISPTNN QANIVDLHPA SVYSIRMYSY
NAIGKSEASK ELTISTEEAQ PDGPPMDVTL QAVTSQSIRV TWKAPRKELQ NGVIRGYQIG
YRENGPGSNG QYSIVEMKAT GDSEVYTLDN LKKFAQYGVV VQAFNRAGTG PSSSEINATT
LEDVPSQPPQ NVRAISVTSD EAVITWAEPP RMTLHGVLKG YRVVFWAVFP DGEWGEMQNI
TTIKEQVELK SLEKFTNYSI QVLAFTQAGD GVRSNVLYIQ TREDLPGPPA GIKAVPSSAS
SVVVSWLPPH KPNGIIRKYT IYCSSPGLGQ PLPSEYEANP ELLFYRITHL NHRQQYLIWA
AAVTTAGRGN FSDKVTVEPA AKAPAKILSF GGTVTTPWMK EVRLPCSSVG EPTPSIKWTK
DSEDTAIPVS VDGQRLILAN GTLVLRSVKA EDSGYYTCTA TNTLGFDTII VNLLVQVPPD
QPRLTVSSTS TSSITLAWIP GDNGGSSVRG FVLQYSVDNT EEWKDVFISS TERSFKLDNL
RCGTWYKVKL AAKNSVGAGR ISEIIEAKTH GREPQFNKDQ PVFTYINSSH ARLNLQGWAS
GGCPISAVTL EFRPKGTWAW QSVRTNATAD VFLAELREAT WYELKMKACN SAGCGNQSSQ
FATLDYDGST IAPIKSPLEK NDDVKKLFSI GCPVILVTVG IALLFIIRKK RKEKRLKRLR
DAKSLAEMLI SKNNRSFDTP VKGPPQGPRL HIDIPRVQLL IEDKEGIKQI GDDKATIPVT
DTEFNQTGNP QSFCTGVSVH HPALIQNTGP LIDMSDIRPG TNPVSRKSVK SAHSIRNRYS
SQWTLTKCQA STPARTLTSD WRTVGSQHGI TVTESDSYSA SLSQDTDKGR NSMVSTESAS
STYEELARAY EHAKLEEHLQ HAKFEITECF ISDSSSDQMT TGTNDNADSM TSMSTPSEPG
ICRFTASPPK PQDYDRGKNV AVPIPHRAKS DYCNLPLYMK SDLFFRKRSE HHDPCPVVPP
REASARGLAQ RAYHTQGRHV TMDSAKQHGT GGMSSSSSSS TLPQRTLTMS GSSAQVAQCA
AASASATAAA ASSSSASGGA VGATGGTPGG ASSSSSKMGG SRDSLLESSS SGLSRLQKQR
DGGSGAYSKS YTLV
//
