ID H2LSG8_ORYLA Unreviewed; 593 AA.
AC H2LSG8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=ENTH domain-containing protein {ECO:0000259|PROSITE:PS50942};
GN Name=epn3a {ECO:0000313|Ensembl:ENSORLP00000009030.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009030.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009030.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009030.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009030.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009030.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the epsin family.
CC {ECO:0000256|ARBA:ARBA00010130}.
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DR RefSeq; XP_004071684.2; XM_004071636.2.
DR AlphaFoldDB; H2LSG8; -.
DR Ensembl; ENSORLT00000009031.2; ENSORLP00000009030.2; ENSORLG00000007197.2.
DR GeneID; 101168623; -.
DR KEGG; ola:101168623; -.
DR CTD; 794862; -.
DR eggNOG; KOG2056; Eukaryota.
DR GeneTree; ENSGT00940000158217; -.
DR HOGENOM; CLU_012678_4_2_1; -.
DR OrthoDB; 1532at2759; -.
DR TreeFam; TF313361; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000007197; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR CDD; cd16990; ENTH_Epsin; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12276:SF16; EPSIN-3; 1.
DR PANTHER; PTHR12276; EPSIN/ENT-RELATED; 1.
DR Pfam; PF01417; ENTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00726; UIM; 3.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50330; UIM; 1.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 12..144
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 141..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..367
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 64903 MW; F925E5F64455E88F CRC64;
MQTSSIRRQM KNAVHSYTDA EIKVREATCN DPWGPPVSLM SEISDLTFNV VAFADIMRII
WKRLNDNGKN WRHVFKALVL LEHLVKTGSE RVVKACKENI HSIQTLKDFQ YIDRDGHDQG
ATVREKAKRL ASLLRDEEKL KKERSHALKS KSRVAGLPSP LDRSMSSSSF DSDLPPSYPS
TPSRLPSEIE KALPTSAEEE ERQLKLAIAL SQQDNNKPAQ RAPSIQPAQR APSIQPAQRA
QVQVSPDLDE DTQLKLALSL SQEEHQQEER RRREEDLKLQ KVLEESKRDA DQPKSAFMDL
VDVFAQPVDP PPSDYKWKSP LQAAASAAGT DPWDSLDGPS IPRSDASWMV PPPSYSPPPP
WEPPTKPWDA PQSSVSKPSF SSKDWDIPTN AASSLDAKVK KGSLKENPPR SASPSDGDLF
DEAMDGGHFS ANGRGEGSPD LFDLTKLGES LADSTPRKCK TPEQFLGPTA ATLVDLDNLI
PINSMAMPSN PFMSAPSAPS SINPFQAEQP KLTLSQMGTG STAAAPTAPS LSFSPSLPLS
LNNQGATIPS SFTHPTQPSL DMPRTLPEPL LPFSSPNPQG LQAAQSTQNP FLD
//
