ID H2LSZ6_ORYLA Unreviewed; 1112 AA.
AC H2LSZ6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=RAS protein activator like 2 {ECO:0000313|Ensembl:ENSORLP00000009212.2};
GN Name=RASAL2 {ECO:0000313|Ensembl:ENSORLP00000009212.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009212.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009212.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009212.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009212.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009212.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LSZ6; -.
DR Ensembl; ENSORLT00000009213.2; ENSORLP00000009212.2; ENSORLG00000007349.2.
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000157702; -.
DR HOGENOM; CLU_001727_1_0_1; -.
DR TreeFam; TF105303; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000007349; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 136..254
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 314..507
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 965..1024
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 124167 MW; 216934A37EDE94C7 CRC64;
SSISGLGSSE KSVAIDSPSS SPFRVPGFFS KRLKGSIKRT KSQTKLDRTT SFRLPLLRPA
DADRSRGLPR LKESSSHESL LSPGSGVEAL DLSMEENVLV KPLHSSILGR DFCFEVTYSG
GSKCFSCTSA AERDKWMENL RRTIQPNKDN RRRAENLLRL WIIEAKDLPP KKKYFCELCL
DDILYARTTS KTRHDSLFWG EYFDFSSLPS VHSITVHIYR DVDKKKKKDK NNYVGLVNIP
VSSMTGRQFV EKWYPVSTPT VSKVKGGGPS IRIKSRFQTI SILPMEQYKE FAEFITNNYS
MLCTVLEPVI SVKNKEEMAC ALVHILQSTG RAKDFLTDLV MSEVDRCADH DVLIFRENTL
ATKAIEEYLK LVGQKYLHDA LGEFIKALYE SDEDCEVDPS RCSGSDLTEH RSNLKMCCEL
AFCKIINSYC VFPRELKEVF ASWKQQCVAR GHVQDISKRL ISASLFLRFL CPAIMSPSLF
SLMQEYPDDR TSRNLTLIAK VIQNLANFTK FGNKEEYMAF MNDFLEHEWA GMMRFLSEIS
NPETLSNTPG FEGYIDLGRE LSVLHTLLWD VVSQLDKGEN SFLQATVAKL GPLPRILGEI
TQSLAAPTPL PQQLQRFQHH SSAHNITGSM SSGIQRMFEG AADRYLHSQA HTVYRPLPIP
NGGQGQQRDS LLPSGRSVSL VDLQEVRSLQ DAPQPLPHHE GPCLSRSGSR ASISAAPTPA
SKAPHKDLQP QSAPQVRRLQ PPLTQQRSLQ PLSFQNPVYH LINPANSLST RSAHSLRRDS
SSENLSTESS HNSHSNSDDF GSQEAGKACA ASNSSLDEGG SRRSTQSEEY FSPRRLVRPN
LAQSAATAVA IPRQSTTTGT AHIVKVEQQS RVGGGARTPH SLPVGSSLCS SSSANTEPTP
TAGPSNLQQS SVENVVTSPV EAAVMSPVER TAAWVLNNGQ YEEEGGRGGP IREEGKKTEK
YELEISRLKE CLRASGRRLE EYERRLLAQE QQMKKLMLDY KSRLEDSEER LRRQQEEKDS
QMKSIICRLM AVEEELKRDH AEMQAVIEAK QKIIDAQEKR IGSLDVANSQ LMAALTQVKE
RYSTPNIRNG LSPSNPTKLS ITENGEFKNS SC
//
