ID H2LVU1_ORYLA Unreviewed; 1708 AA.
AC H2LVU1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=ATP binding cassette subfamily A member 3 {ECO:0000313|Ensembl:ENSORLP00000010226.2};
GN Name=ABCA3 {ECO:0000313|Ensembl:ENSORLP00000010226.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010226.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000010226.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010226.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000010226.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010226.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8090.ENSORLP00000010226; -.
DR Ensembl; ENSORLT00000010227.2; ENSORLP00000010226.2; ENSORLG00000008142.2.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155289; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; H2LVU1; -.
DR OrthoDB; 6951at2759; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000008142; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1141..1169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1181..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1215..1233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1306..1324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 525..758
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1383..1616
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1708 AA; 191521 MW; 52D955E62417A9C0 CRC64;
MAVVRQFGLL VWKNYLQQKR QILVTLVEIL LPLLFSGILI VLRQKVAFKD YPNATIYESY
YVDELPKPFL RSFQLAFVPS NSSVVRRVAE DVRGSLYLSS VHGFETEEQF EEYVKNDPSS
GQLLAAVVFD HPFTHDDDPL PLQVSYHLRF TFTPRNAPPK EKSELNPNSD LDWHTLSLFP
LFQMPGPREQ YDKEGGTPGY FREGFLAVQH AVDRAIMHSY NRTAAAALLR QTRVVLSRFP
YPAFIYDVFI LAIQNQLPLL LVLSFTYTAL NIVRAVVQEK ERKLKEYMRM MGLSNWLHWS
AWFLMFFLFL SISVFFVTVL LCIQVSPNGA VLTYSDPTLV FFFLLLFTVA TISFSFMISA
FFSRANVAAA AGGFIYFLSY LPYLFLWPRY DLLSHGQKVS ACLISNVAMA MGAQLIGMFE
GKGTGIQWSN LFDSVTVDDD FSLAQVLCLL LFDSVLYGLV AWYVEAVFPG EYGVPLPSYF
FLLPSYWCSS PRMALVNEKE EEEDAEKALK GEFIEEEPAG LVSGVKIKHL SKEFKLGNKT
RRAVRDLTLN MFEGQITVLL GHNGAGKTTT LSMLTGLYPP SSGRAYINGY DICQDMALIR
RSLGLCPQHD VLFDNLTVRE HLLFYAQLKG YSKDKIPDEV DRIIRILNLE DKRRARSKTL
SGGMKRKLSI GIALIGDSKV VMLDEPTSGM DPSARRATWD LLQGEKRGRT ILLTTHFMDE
ADLLGDRIAI MAGGELQCCG SPLFLKNKYG AGYHMVIVKD AFCNVSEITR LVHMYVPNAT
LESSAGAELS YILPKESTSR FELLFAELEM NRDELGIASY GASVTTMEEV FLRVGKLVDS
SLDIQAIQLP ALQYQHERRS HDWNMEDTSS ISGLTDVTDF TDSGTLISED CSSIKLNTGV
RLHLQQFYAM FLKRALYSWR NWKVMVAQFL VPLIFTVMAL VVARTFPNHQ NAPSLNLKLS
RYGPTRVPVA LQGGAGPLAH ALANTYISQL STQIGELVNI TDFTDYVLTH AEEEGGSFNE
RCVVGAAFRG IGRQFAEATA YFNNQGYHTP ATALMMVDNA LFKLLAGPNA SIQTSNYPMP
RNLSETARSQ LTEGKTGFAI AINLMYGMAS LSSTFALLLV TESSLKSKHV QQVSGVYLSN
FWFSALLWDL VNFLLPCLLM LVVFQGFGVE AFVDGNHLID VLLLLLLYGW AVVPLMYLLS
FLFSTAATAY TRLTIFNMIS GTATFLAVTI MTIPELNLQH LSHLLDKVFL IFPNYCLGMS
FCQFYQNYQF ITFCTSSSLS QIICKYMNIT YQENYFSMSE PGVGRFLVAL SVQGVVFNML
LFVIELQCVR TICRLLKSLG RRRKQLPLIE DAALVPEDRD VAEERKRVLE CQPMMESMVG
SPLILQELSK VYSSGESLLA VDRLSLAVAK GECFGLLGFN GAGKTTTFKM LTGDESVTSG
DAYIDGYSIL RDIKKVQQRI GYCPQFDAVL DHMTGRETLC MYARLRGIPE KYVSGCVENV
LRSLLLEPHA DKLVRSYSGG NKRKLSAGMA LIGGPPVIFL DEPSTGMDPV ARRLLWDAIT
HIRESGKAIV ITSHSMEECE ALCTRLAVMV NGQFKCLGSP QHLKSKFGSG YTLLAKVHVE
AELEESDLRV FKDFIESTFP GSQLKDEHQG MVHYHLTDKA LTWAQVFGTL EAAKEKYQIE
DYCVSQISLE QVFLSFAQFQ HCTQAGRK
//
