ID H2LYQ3_ORYLA Unreviewed; 741 AA.
AC H2LYQ3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Synaptotagmin like 5 {ECO:0000313|Ensembl:ENSORLP00000011272.2};
GN Name=SYTL5 {ECO:0000313|Ensembl:ENSORLP00000011272.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011272.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000011272.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011272.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000011272.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011272.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004081563.1; XM_004081515.2.
DR AlphaFoldDB; H2LYQ3; -.
DR STRING; 8090.ENSORLP00000011272; -.
DR Ensembl; ENSORLT00000011273.2; ENSORLP00000011272.2; ENSORLG00000008988.2.
DR GeneID; 101155809; -.
DR KEGG; ola:101155809; -.
DR CTD; 94122; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000158618; -.
DR HOGENOM; CLU_002711_5_0_1; -.
DR InParanoid; H2LYQ3; -.
DR OrthoDB; 590187at2759; -.
DR TreeFam; TF341184; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000008988; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0070382; C:exocytic vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042043; F:neurexin family protein binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04029; C2A_SLP-4_5; 1.
DR CDD; cd04020; C2B_SLP_1-2-3-4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR037303; SLP-4/5_C2A.
DR InterPro; IPR043567; SYTL1-5_C2B.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45716; BITESIZE, ISOFORM I; 1.
DR PANTHER; PTHR45716:SF6; SYNAPTOTAGMIN-LIKE PROTEIN 5; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 7..125
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 415..537
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 573..705
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 145..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 82195 MW; BF05E6FD1361DEA7 CRC64;
MEKVEEDLNL SFLLDHEREM ILKVLQKDEK LRKQEEKRIR KMKNELLEIK HKGFPRPQES
GDRLCARCLK TLGLIFDRGE LCEECQQRVC SECRALTANS RKWRCNVCAK VLELKVVSGE
WFLEERSKRF EQQVMSSDVI KHTILTSPPS AEKKPAEKPP VSPNPEKHGK SKPGRSAIRN
IVDGAKKKGR MKADKKGGRS NLKPEDRVDG ASAKSASDGE SHSSGSVGSA QSTYSNRSAA
VAVESSGLTT VPNNLRSQTP AKSSTPGETR RVRPDGAESV SSLQSGDSLP EKKASGHHRK
SSGTPAISVS RVSLSSDRSH SEMDLSAFGS EPSDDALTQA GFSDEDVEED IDALVPSYSP
SPKLYLSSAV STSSTPASER RWGYLSVPDS DAETSSINSM TSMYSETGDY GNARVSGEIL
MNISYSYKTG ALNVLVKECH NLATGDERKQ RTDAYVKTYL LPDKSRQSKR KTSIKANTIN
PVFNESLRYV ISHSQLELRT LQVSVWHHDR FGYNSFLGEV ELSFDSWEFD SQIEEWYALQ
PRVDGSTDST MHYKGELTVV LKYIPAEINT TPPPDQVQVK KGFLKGKKTS SFTLPKGGMV
ELLVKGAKNL TAVKAGGYSD PFVKGYLLPD SNKSTKHKTA VERRTVNPHW NHTFTYCGLQ
PGDLNNICLE LTVWDKEALA SNVFLGGVRL GAGTGNSYGN EVDWMDSYGE EQRVWQRMIE
TPGVPHECTL LLRSSMRKRN T
//
