ID H2M2A2_ORYLA Unreviewed; 897 AA.
AC H2M2A2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Integrator complex subunit 6 like {ECO:0000313|Ensembl:ENSORLP00000012542.2};
GN Name=ints6l {ECO:0000313|Ensembl:ENSORLP00000012542.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000012542.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000012542.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012542.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000012542.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000012542.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011478821.1; XM_011480519.1.
DR AlphaFoldDB; H2M2A2; -.
DR STRING; 8090.ENSORLP00000012542; -.
DR Ensembl; ENSORLT00000012543.2; ENSORLP00000012542.2; ENSORLG00000009994.2.
DR GeneID; 101161250; -.
DR KEGG; ola:101161250; -.
DR CTD; 203522; -.
DR eggNOG; KOG3768; Eukaryota.
DR GeneTree; ENSGT00390000016655; -.
DR HOGENOM; CLU_006789_0_0_1; -.
DR InParanoid; H2M2A2; -.
DR OrthoDB; 50779at2759; -.
DR TreeFam; TF323386; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000009994; Expressed in animal zygote and 15 other cell types or tissues.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12957; DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED; 1.
DR PANTHER; PTHR12957:SF22; INTEGRATOR COMPLEX SUBUNIT 6-LIKE; 1.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 3..227
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 638..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 99928 MW; BA24D48ECD09224A CRC64;
MPILLFLLDT SASMNQRTYL GTTYLDVAKG AVEVFMKLRA RDPASRGDRY MLVTFDEPPY
GVKAGWKENH ATFMCELKNL QASGLTTLGH ALRTAFDLLN LNRLVSGIDN YGQGRNPFFL
EPSVIITITD GNKLTHSSGV PDELHLPLNS PLAGSELTKE PFRWDQRLFA LVLRLPGASA
PDSEQLGSVP TDESAITQMC EVTGGRSYCV RTQRMLNQCL ESLVQKVQSG VVLHFEKTGP
DPIVVEENSA ESSQPAQSFS PNAWHSCHKL IYVRPNPKTG VPVGHWPIPE SFWPDQNSPT
LPPRSAHPLV RFSCVDCEPM VIEKLPFDKY ELEPSPLTQY ILERKSPHMC WQVFVSNSGK
QTDLGQPFGY LKASTTLTCV NLFVMPYNYP VLLPLLDDLF KVHKLKPNLK WRQAFELYLK
TTPPYYLLPL KKALRMMGAP NLIADTLDCG LSYSVISYLK KLNQQAKVES DRLIVSVGKK
APQESGIKVK NHSSSLLLAH RGDFKQLLQG ITGEGPLRLA DINFKEFAGF QIALLNKDVK
PQAYRNAYDI PRRNLLDQVT RMRSNLLRTS LRLIRGQDED YLHSIPVAQM GNYQEYLKMM
PSPLREIDPD QPKRLHTFGN PFKQDKKGMM IDEADEFVAG PQNKKRGMSG DPNSNATLKR
RRSMSPLLRR PQTPPGNNHA AAGKALSGVQ TPQSLLKPAP QHKGGGICTP ATESNGDGVS
GPDSAESWQN ETDADPEPPS LLGLEEKAVA ADQEDDVRAV EDRPPLDPLE DPPPETKHSL
ERLSPQSEPD DADADVDADA DVALETIFIA PLDGSQAELR SQVIKEVRKP GRNHKAILGL
LQQVKGPETV KRFFIHHAIK EAARFKKRVL IQQLEATLQE LEEQQPPCLQ LHNDHGS
//
