ID H2M4D5_ORYLA Unreviewed; 507 AA.
AC H2M4D5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Galactose-3-O-sulfotransferase 4 {ECO:0000313|Ensembl:ENSORLP00000013300.2};
GN Name=gal3st4 {ECO:0000313|Ensembl:ENSORLP00000013300.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000013300.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000013300.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013300.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000013300.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000013300.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the galactose-3-O-sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00008124}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011486028.1; XM_011487726.1.
DR AlphaFoldDB; H2M4D5; -.
DR STRING; 8090.ENSORLP00000013300; -.
DR Ensembl; ENSORLT00000013301.2; ENSORLP00000013300.2; ENSORLG00000010608.2.
DR GeneID; 101162323; -.
DR KEGG; ola:101162323; -.
DR CTD; 79690; -.
DR eggNOG; ENOG502QSHR; Eukaryota.
DR GeneTree; ENSGT00950000182923; -.
DR HOGENOM; CLU_040616_1_1_1; -.
DR InParanoid; H2M4D5; -.
DR OrthoDB; 3032344at2759; -.
DR TreeFam; TF314802; -.
DR Proteomes; UP000001038; Chromosome 18.
DR Bgee; ENSORLG00000010608; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050694; F:galactose 3-O-sulfotransferase activity; IBA:GO_Central.
DR GO; GO:0001733; F:galactosylceramide sulfotransferase activity; IEA:InterPro.
DR GO; GO:0009247; P:glycolipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR009729; Gal-3-0_sulfotransfrase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR14647; GALACTOSE-3-O-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR14647:SF57; GALACTOSE-3-O-SULFOTRANSFERASE 4; 1.
DR Pfam; PF06990; Gal-3-0_sulfotr; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 474..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 57519 MW; 1FDE67BD61941A54 CRC64;
MFIRLTARIL RWLVCGRVGP LWMWKALLLF VAVVFAGQLL GVIFNKSGVQ PAGHSIFSSP
DAQGPSLGSC RPHTHIMFLK THKTASSTVL NMLYRFGEEH NLRFALPLGY QLGYPLPFNA
HRVKGYRGPG ALEFHIMGNH MRFNKMEVEK VMPADTFYFS IVRDPVALTE SSFAYYKEVA
PAFRKAKGLG DFADDPNKYY DPRLRNNQYA RNLLWFDFGL DHNANFSLAL AQRGEDLIRR
TFKLILISEY FDQSMVLLRH ALCWPLDAVV SFSLNARQQK ASVGGMSGIW MGKAAAAAGV
GGGRPQARIP PNLSLTGDQR EKLRQWNALD WYLYKAFNRT FWEEVDKFGR KHMEQEVSLL
RMRREHLARV CLRDGGKPVE AHRIRDKNIR PFQSGFVRIL GYELQPGLDN ATRMSCLRMI
RPEIQYKDLL DSKQFPQVPP IQAPQNPLLI AAGAGSFLRA ESRNREEPVG FEIGGRTMEE
GGKDWDGSRL VRRNQTGIRG SGTGRSP
//
