ID H2M8C9_ORYLA Unreviewed; 504 AA.
AC H2M8C9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Transportin 2 {ECO:0000313|Ensembl:ENSORLP00000014744.2};
GN Name=TNPO2 {ECO:0000313|Ensembl:ENSORLP00000014744.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000014744.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000014744.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014744.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000014744.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000014744.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2M8C9; -.
DR STRING; 8090.ENSORLP00000014744; -.
DR Ensembl; ENSORLT00000014745.2; ENSORLP00000014744.2; ENSORLG00000011763.2.
DR eggNOG; KOG2023; Eukaryota.
DR GeneTree; ENSGT00940000156708; -.
DR HOGENOM; CLU_008136_0_0_1; -.
DR InParanoid; H2M8C9; -.
DR TreeFam; TF300825; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000011763; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF17; TRANSPORTIN-2; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 31..99
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 338..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 56914 MW; DC8BA03C7C319CD2 CRC64;
MEWQPDEQGL QQVLQLLKDS QSPDTATQRA VQEKLEQLNQ FPDFNNYLIF VLTSLKSEDE
PTRSLSGLIL KNNVKAHYQN FPPNVADFIK RECLNNIGDP SPLIRATIGI LITTIASKGE
LQMWPELLPQ LCNLLNSEDY NTCEGSFGAL QKICEDSSEL LDSDALNRPL NIMIPKFLQF
FKHCSPKIRS HAIACVNQFI IGRAQALMDN IDTFIESLFA LAGDEDCEVR KNVCRALVML
LEVRIDRLIP HMHSIIQYML QRTQDPDENV ALEACEFWLT LAEQPICKEA LSGHLVQLIP
ILVNGMKYSE IDIILLKGDV EEDETVPDSE QDIKPRFHKS RTVTLQHEGG EGEEGEDIDD
DEDDDDDTLS DWNLRKCSAA ALDVLANVFR EELLPHLLPL LKGLLFHPDW VIKESGILVL
GAIAEGCMQG MVPYLPELIP HLILCLCDKK ALVRSIACWT LSRYAHWVVS QPPDAHLKPL
MTELLTRILD GNKRVQEAAC RCCT
//
