ID H2MA18_ORYLA Unreviewed; 526 AA.
AC H2MA18;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Poly-U binding splicing factor b {ECO:0000313|Ensembl:ENSORLP00000015365.1};
GN Name=puf60 {ECO:0000313|Ensembl:ENSORLP00000015365.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015365.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015365.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015365.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015365.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015365.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM half pint family.
CC {ECO:0000256|ARBA:ARBA00005987}.
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DR RefSeq; XP_004081203.1; XM_004081155.2.
DR AlphaFoldDB; H2MA18; -.
DR STRING; 8090.ENSORLP00000015365; -.
DR Ensembl; ENSORLT00000015366.2; ENSORLP00000015365.1; ENSORLG00000012279.2.
DR eggNOG; KOG0124; Eukaryota.
DR GeneTree; ENSGT00940000155594; -.
DR InParanoid; H2MA18; -.
DR OMA; VHTHKGY; -.
DR TreeFam; TF313987; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000012279; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006376; P:mRNA splice site recognition; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12370; RRM1_PUF60; 1.
DR CDD; cd12371; RRM2_PUF60; 1.
DR CDD; cd12648; RRM3_UHM_PUF60; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR006532; PUF60-like.
DR InterPro; IPR034209; PUF60_RRM1.
DR InterPro; IPR034211; PUF60_RRM2.
DR InterPro; IPR034212; PUF60_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR NCBIfam; TIGR01645; half-pint; 1.
DR PANTHER; PTHR47330:SF1; POLY(U)-BINDING-SPLICING FACTOR PUF60; 1.
DR PANTHER; PTHR47330; POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 3.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 99..177
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 196..274
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 429..516
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 56515 MW; F936A4D930F7E3C4 CRC64;
MAVTETAGGE ALKMENGQGT GSKLGLPPLT PEQQEALQRA KKYAMEQSIK SVLVKQTIAH
QQQQLTNLQM AAVTMGFGDP LSPLQSVAAQ RQRALAIMCR VYVGSIYYEL GEDTIRQAFA
PFGPIKSIDM SWDSVTMKHK GFAFVEYDVP EAAQLALEQM NSVMLGGRNI KVGRPSNIGQ
AQPIIDQLAE EARAYNRIYV ASVHPDLSDD DIKSVFEAFG RIKSCMLARD PTSGRHRGFG
FIEYEKPQSA VDAVSSMNLF DLGGQYLRVG KAVTPPMPLL TPTTPGGLPP AAAVAAAAAT
AKITAQEAVA GASVLGALAA PQLLGQQIGI PQAVMAAQAP GVITGVTPVR PAIPVIPQVG
LVNPVLASPP VLSNQAASSS QQEKKEEKEE ALQDGTGQEM LSDQEHMSIS GSSARHMVMQ
KLLRKSESTV MVLRNMVGPE DIDDDLEGEV TEECGKFGTV NRVIIYQEKQ GEEEDADIIV
KIFVEFSAAS EMNKAIQALN DRWFGGRKVV AEVYDQDRFN SSDLSA
//
