ID H2MA44_ORYLA Unreviewed; 1823 AA.
AC H2MA44;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=P-type domain-containing protein {ECO:0000259|PROSITE:PS51448};
GN Name=si {ECO:0000313|Ensembl:ENSORLP00000015392.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015392.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015392.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015392.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015392.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015392.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004655}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004655}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004401}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8090.ENSORLP00000015392; -.
DR Ensembl; ENSORLT00000015393.2; ENSORLP00000015392.2; ENSORLG00000012288.2.
DR eggNOG; KOG1065; Eukaryota.
DR GeneTree; ENSGT00940000164162; -.
DR HOGENOM; CLU_000631_3_0_1; -.
DR InParanoid; H2MA44; -.
DR OrthoDB; 5480935at2759; -.
DR TreeFam; TF314577; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000012288; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004558; F:alpha-1,4-glucosidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06602; GH31_MGAM_SI_GAA; 2.
DR CDD; cd14752; GH31_N; 2.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 4.
DR Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 2.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF168; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 2.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 2.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 2.
DR Pfam; PF00088; Trefoil; 2.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 2.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..95
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 924..968
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
SQ SEQUENCE 1823 AA; 207241 MW; 2A4078D83917B097 CRC64;
MGKRRFSSME VTLLVLFVLM TATAVTMIAL YFTREPKSIQ DETNEGFIPV CPNVAQAERV
DCFPETGASQ LTCEQRGCCW SPLDTPNVPW CFFSSNHGYT AHSVKHPNPH EITAELSRMP
SPSLFGADIQ QLSFHAEMQT SNRLRFKIFD AQQKRFEVPH EHINTVTSNP STPISDALEI
TNEPFGLIVR RKENKKVLFD TTFAPLVFAD QFLQLSAKLP SHNIYGLGEH VHQNYRHDTN
WRTWPIFSRD AFPNGGTHNL YGHYPFFLCL EDNSGNSFGV FLLNSNAMEV TLQPAPAVTY
RTIGGILDFF IFFGETPEQV VQEFEELIGR PVIPPYWSLG FQLSRWNYGS LSEVKKTVER
NRAVGLPYDI QYTDIDYMEE KKDFTYDKVN FKDLPTFADY LHEKGQKYIL ILDPAIATSK
LIGDVAYGSY DRGTAKNAWV TESDGKTHLV GEVWPGETVF PDYTSQNCID WWVDEYDRLY
KEVKHDALWI DMNEVANFKQ GSSKGCSVNK LNYPPYTPRI LDDLMYSKTL CMDAKQAWGN
HYDVHSLYGY SMVLATEQAL QRVFGGNRTL MLTRSSFPGV GKYSGHWLGD NGANWNDIKW
AIPGMLEFGL FGVPYIGADI CGFFDDSSEE LCRRWMQVGA FYPFSRNHNA EGYKPQDPAS
YGASSLLVAT SKHYLSIRYT LLPYLYTLFY KAHTSGDTVV RPLLHEFYSD SDTWAVDRQF
LWGKYLLITP VLDPGVESVQ GYFPDAVWYD YETRERLGQR KTHVELFLPA DKLGLHIRGG
AILPTQEPDV TTTHSRLRPM GLIIALDDNN QATGELFWDD GDSRATVENG KYIHYDFSVV
DNVLAMDVTN AGYSDPNNLK FETITVLGVP HAPSAVFVIH IGPGGASDPV EIKNTSIHHD
ATKEVLTLND LSLTLGESYK VQWDSVTLDY QRVDCHPEEN SNEAECKKRG CLWEVSAAEN
VPWCFYPDDY GYNVLNYAET TTGIRVDINR NTRYRSSGRP DSPDIDSLRV EINYHTGDML
QFKIWDPSTE RFEVPVPLTV PSTPESDEDK RLYRVSVTES PFGIQVVRKS TGTTVWDSSM
PGFIFSNMFI QISTKLSSKF VYGFGETEHT SFKHDLDYHT WGMFAKDQPP GYKMNCYGVH
PFYMGLENTG DAHGVLLLNS NAMDVTFQPT PSLTYRTIGG ILDFYMVLGP TPEMVVQEYT
SLVGRPVLPA YWSLGFQLCR YGYANDSEIE NLYTDMKKAG IPYDVQYADI DYMERQLDFV
LDSEFQGLPA LVDQMRAEGM RFIFILDPAI SGNETNYPAF ERGVAQDVFI KWPKELGDGI
VWGKVWPDFP NVTVDEDLDW ETQVQIYRSY AAFPDFFRSQ TAAWWHQEIQ DFYTNVMKFD
GLWIDMNEPA SFVHGTVGGT CLGENLLEFP PYMPPLESKE EGLKHKTLCM NSEQILSDGK
RVKHYDVHNL YGWSHTKPTY DALLDVTGKR GIVVTRSTYP SSGKWAGHWL GDNNSSWDQL
YKSIIGMMEF SLFGIPYTGA DICGFFNEAD YEMCLRWMQL GAFYPYSRNH NGKGNPRQDP
VAWDDRFATI SKDVLNIRYT LLPYLYTLMF EAHTQGSTVV RPVLHEFTND KTTWDIHRQF
LWGPALLISP ALDAGQTVVN GYLPVARWYD YHSAQDVGVR GKWLTMQTPL ERINLHVRGG
YILPWQKPES NTKLSRKNPL GLIVALSDSG TAEGSFFWDD GEGIDTVEQK KYLHATFSTA
SNTLTNKVVH NGLNPEDRLT LGSVKVWGTG TEKITEVTLT DSTGKIHQVI PQQNIYTQEL
IIDVTVLAVY LDLPFTIEWK SVV
//
