ID H2MAZ9_ORYLA Unreviewed; 743 AA.
AC H2MAZ9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Rho GTPase activating protein 44 {ECO:0008006|Google:ProtNLM};
GN Name=LOC101158144 {ECO:0000313|Ensembl:ENSORLP00000015713.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015713.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015713.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015713.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015713.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015713.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2MAZ9; -.
DR Ensembl; ENSORLT00000015714.2; ENSORLP00000015713.2; ENSORLG00000012549.2.
DR GeneTree; ENSGT00940000157296; -.
DR HOGENOM; CLU_013806_0_0_1; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000012549; Expressed in gastrula and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07619; BAR_Rich2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF13; RHO GTPASE-ACTIVATING PROTEIN 44; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 14..249
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 255..445
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 464..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..717
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 82511 MW; 6A136E650083B515 CRC64;
MKKQFNRMRQ LANQTVGRAE KTEVLGEDLL QVEKRLELVK QVSHSTHKKL TACLQGQQGV
DVEKKSKKLP LTTLAQCMVE GAVVVGDESL LGKMLKLCGE TQERLAQELI LFELTIERDV
VDPLCELAEV EIPNIQKQRK HLAKLVLDMD SARTRYYQST KSSGVSTNLQ PTGAKADHLR
EEMEEAANRM EICRDQLSAD MYSFVAKEID YASYFQTLIE VQAEYHRKSL ELLQSVLPQI
KAHQETWVEK PCYGKPLEEH LVLSGRDIAF PIEACVTMLL ECGMEEEGLF RIAPSASKLK
KLKASLDCGV LDVQEYSADP HAIAGALKSY LRELPEPLMT FQLYSDWIQA SNIQDHEKRL
QALYAACEKL PPANNNNFKY LIKFLSKLTE YQDLNKMTPG NIAIVLGPNL LWTHNDGNIT
EMMTTVSLQI VGIIEPIIQH ADWFFPGEIE FNVTGNYGSP VHTNHNANYS SMPSPDMDQT
DRRQNDQSRR PLSVATDNMM LEFYKKDGMG VRVMDTSWVS RRGSSSSRKS SSTPPNVHPP
TPPADAIIPE QPGDFYVSPS PTPPPTSSKT EEGCSEYVGK LFFFYLTNLQ LYWFHICVTL
NRYNLAFCCL SAKKLAPIPP KGPFCQMGAM SDQSTGQPSP VSLSPTPPST PSPYGFSYPQ
GYATISSPCQ TQTATTPSLS SPPSLAGTLN KPRPIPKPPR QRPNLPPPQP PSTPGTSPQP
LDHSSGLLDG LSPGESMSTG NCN
//
