ID H2MBF4_ORYLA Unreviewed; 264 AA.
AC H2MBF4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC101168676 {ECO:0000313|Ensembl:ENSORLP00000015875.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000015875.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000015875.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015875.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015875.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015875.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC {ECO:0000256|ARBA:ARBA00005406}.
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DR RefSeq; XP_004085378.1; XM_004085330.2.
DR AlphaFoldDB; H2MBF4; -.
DR STRING; 8090.ENSORLP00000015875; -.
DR Ensembl; ENSORLT00000015876.2; ENSORLP00000015875.2; ENSORLG00000012671.2.
DR GeneID; 101168676; -.
DR KEGG; ola:101168676; -.
DR eggNOG; ENOG502S1HV; Eukaryota.
DR GeneTree; ENSGT00390000017291; -.
DR HOGENOM; CLU_067834_2_1_1; -.
DR InParanoid; H2MBF4; -.
DR OrthoDB; 4265952at2759; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000012671; Expressed in intestine and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0003953; F:NAD+ nucleosidase activity; IBA:GO_Central.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IBA:GO_Central.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IBA:GO_Central.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003193; ADP-ribosyl_cyclase.
DR PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR PANTHER; PTHR10912:SF9; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR Pfam; PF02267; Rib_hydrolayse; 1.
DR SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 264 AA; 29073 MW; CDDE46DEE9B9FE4B CRC64;
MRRMVVFVVV GVVVVSVALG LGLGLGLTIG RRSGGIKDTF LKRCQKFKDL NCQNVWDAFQ
RAYINRDPCT VTTDAYDPFI EAVSFKPQCN RVLFWSKTKE VAHSFTQKRD CLVTLEDTPL
GAMVDGLTWC GKKGSNETFS SGCPEYSACE NNPMRSYWNR ASAALADAAC GDVSVMLSGS
IQTPFDPESI FATIEVTRLH SPRVRRLNVV LVMEKNAVTN CENKSLKNLQ NVLDAGIGYG
CKEVTRDQID KCSSDPEIAC GACW
//
