ID H2MFQ8_ORYLA Unreviewed; 1129 AA.
AC H2MFQ8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Si:dkey-119f1.1 {ECO:0000313|Ensembl:ENSORLP00000017434.2};
GN Name=si:dkey-119f1.1 {ECO:0000313|Ensembl:ENSORLP00000017434.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000017434.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000017434.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017434.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000017434.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000017434.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC {ECO:0000256|ARBA:ARBA00006793}.
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DR AlphaFoldDB; H2MFQ8; -.
DR STRING; 8090.ENSORLP00000017434; -.
DR Ensembl; ENSORLT00000017435.2; ENSORLP00000017434.2; ENSORLG00000013905.2.
DR eggNOG; KOG0250; Eukaryota.
DR GeneTree; ENSGT00550000074816; -.
DR HOGENOM; CLU_009063_0_1_1; -.
DR InParanoid; H2MFQ8; -.
DR TreeFam; TF314520; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000013905; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR PANTHER; PTHR19306:SF7; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 101..328
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 46..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 281..315
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 355..396
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 711..759
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 788..934
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1129 AA; 130319 MW; 02D4B7B466623449 CRC64;
MTCVKREVGS LVSTTPARSF FQFRFAASLL TLNNIIMSKR RSSTVIENPD KRIRSDAEAE
EEEDDKEEEE EEDIADHRDH HRDVPQRCAG DVVSDAGILE SITLKNFMCH SLLGPFAFGS
NVNFVVGNNG SGKSAILTAL IVALGGNAHA TNRGSSLKDF VKEGESSADV SITLRNKGKD
AFKLEVYGPL ITVEMRITRD GLRTYKLRSK DGQIISTKKE ELISILDNFN IQVNNPVSVL
TQEMSKHFLH SKGEGDKYKF FMKATQLEQM RETFVYIKAT KQATQHKIEQ QNEHLKRLRE
DYKREEERYK SLASVDEIQT KLEELQKEMA WALVSELEHN LEPKKEKLEA DRRSTQKYDE
KVNEWKSKVE EAEKKYKQTE EDLERITQQV QELQPKCVEL KTEAQRRNNL LKSCEVTVHR
CKANLRDLDK DKVQLSTRIK DLKVSFSQST GAESQARAER MSQIQAELEN LNHQNSTLVQ
QIEQYGMANI RTREEQGKVR MEHETIKKSI EASSRNLRIL ESSRSNRLRR FGEHMPNLLD
AIEVAHRRGQ FKHKPRGPLG YLISLKDSEL ALAVEICLKN QLHAFTCDNY EDEKVLQDLM
KKCYPSGRRP SIITSPFFPK VHDTRRRAVN HPEFPSVLQA LEIEDPVVAN CLIDQRGIES
ILLIKNNTQA RKVMLGKNPP RNCTQAFSKE GDQIYTNRVY SADQTRANCL SGDVEEEIRL
LQRELENQKA QEFRFQQQMK KLENEIKQNE ILIKKCQMTQ KSTKDKMTKL QLELTDLQNI
EEPQSEDLKA LEEDLQEVIA KISSKQAEYD EARDQMSKLK ENYEEAEQEY KQHKESINTL
IEEADSVKED LSKTDQEVVR CKHHTKHYEE KRSAHLKNIQ SLEAELRSKE EELQESAAKA
AQICPERLDA CRPAKSLDSE INRMKVKIAT QQEQQGDRSE IVRQFVKARE SYKSMSQQIR
NLNSFIYSLT SVMNKRLQAY TEFRKFFSAR CKYYFNSMLA QRGYSGSMIF DHKNETLSIT
VQPGQGNTAD LSDMRSLSGG ERSFSTVCFV LSLWAITEAP FRCLDEFDVY MDMVNRRISM
DMMLKVASGQ RFRQFIFLTP QNMSSLPICS NIRILRLKDP DRGQNNSSK
//
