ID H2MK10_ORYLA Unreviewed; 950 AA.
AC H2MK10;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Sorting nexin 19 {ECO:0000313|Ensembl:ENSORLP00000019014.2};
GN Name=SNX19 {ECO:0000313|Ensembl:ENSORLP00000019014.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019014.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000019014.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019014.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000019014.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019014.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR STRING; 8090.ENSORLP00000035971; -.
DR Ensembl; ENSORLT00000019015.2; ENSORLP00000019014.2; ENSORLG00000015174.2.
DR Ensembl; ENSORLT00000041629.1; ENSORLP00000035971.1; ENSORLG00000015174.2.
DR eggNOG; ENOG502QQBH; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_012033_0_0_1; -.
DR OrthoDB; 2919310at2759; -.
DR TreeFam; TF324055; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000015174; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR CDD; cd06893; PX_SNX19; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037909; SNX19_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF31; SORTING NEXIN-19; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..252
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 489..638
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 256..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 104192 MW; B805C54E5D8EEC47 CRC64;
MADVVGQRGL LALGLLLAWM LLFHLLVNIW LLCVFTSLLV VLGGWLGSQA VLESDSVLHL
ERFIPLEPGP PSLEDELHLD QEIRDTVRKI IRDFVSSWYS SVSSEGRLEA ELHQAMSSMA
VELKLRARKV DRKDLAEKVL HVWGGHLQDF LEAKELQVEK SSGELQPLWA AFSSISSPHP
ALNSPTEEVH YIRAVAGLLL QVLVPPPHLE TRSGRFVVEE LVSCGVLLPL VEKLSDPDWL
NLLIIDVFGE ASVPLETAAG DPTSPSQHAL CAEPEQDPMA PPEQAADPPY VDCEAPGGRV
EDGSDAALPE AAPCDVVDSE GGELTHSLTE DDPPLFLRHF LRSSKANPFY LENDSDLDSP
LAEDKPGSMD SLVMVGQGEG LFEGQQDCAP LAENSPRLEL EEKVTVSLEL VEDQGCSSVS
SAGGAHSSRQ DLDQPGSGAG TPHRELLLSV EQAGNELSVG SPLQGGACMP TFSFEPLCSP
EGPVLIQNLR ITGTITAKEH RGTGSHPYTL YTIKYETSVA CEKTGGLQSV SENGEGLQTD
ENSCPGQPVA YHMVNRRYSE FLNLQTRLEE KPELRRLIKG VKGPKKMFPE MPFGNMDSEK
IEARKGLLET FLKHLCAMPE IANSEEMQEF LALNTDARIA FVKKPFIVSR IDKMVVSAIV
DTLKTAFPRS EPQSPTEDND GELDGGKLCA DKRNRSRLKL SGKSVPLVNG SDVRAPVLFS
WDHSASMFHG MSLEDLDAFL QKQEQLSAGA EGGEQVHLGS GQQGGGADVQ RGEQRHGEML
LADVALNLLC LLMKQQWSWL CSENVQKAVR LLFGTLIDRW LDVSVANLTS TRYWVAYLQV
IQEAVWPGGV LPAGPGPERS QQQKELTKQR ALESLMRLVP DAVSELLGSE PYRLSWQTVL
DSFQDPFINR HLVFSLLDLL LDVLVPEAAD EAWQRAVLQD PPKNPEKLLD
//
