ID   H2MKI9_ORYLA            Unreviewed;       685 AA.
AC   H2MKI9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=FAD-dependent oxidoreductase domain containing 2 {ECO:0000313|Ensembl:ENSORLP00000019204.2};
GN   Name=foxred2 {ECO:0000313|Ensembl:ENSORLP00000019204.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019204.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000019204.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019204.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000019204.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019204.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2MKI9; -.
DR   STRING; 8090.ENSORLP00000019204; -.
DR   Ensembl; ENSORLT00000019205.2; ENSORLP00000019204.2; ENSORLG00000015336.2.
DR   eggNOG; KOG1399; Eukaryota.
DR   GeneTree; ENSGT00640000091519; -.
DR   HOGENOM; CLU_014290_1_0_1; -.
DR   InParanoid; H2MKI9; -.
DR   OrthoDB; 2665879at2759; -.
DR   TreeFam; TF324712; -.
DR   Proteomes; UP000001038; Chromosome 8.
DR   Bgee; ENSORLG00000015336; Expressed in animal zygote and 10 other cell types or tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR43539:SF78; FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR43539; FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220); 1.
DR   Pfam; PF13738; Pyr_redox_3; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..685
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017482606"
SQ   SEQUENCE   685 AA;  78123 MW;  725E479AE472583F CRC64;
     MEPGLPCFIF FTLVGFVFTS FNDFHRNNTQ HHDYCVLGAG PAGLQMGYFL SKAKRDYIIL
     ERNSGPGSFF KKYPRHRKLI SINKIHTGRR NREFNLRHDW NSLLSDRPDL LFKRVSSEFY
     PPADKLPLYL SMFEKELGLK VQYRVDVGRI RAVESAAERS YILTDQQGGD YTCRVLLVAT
     GLWVPQVVEF VGSDLVEGYE SISTNPEDYK DQAVLILGKG NSAFETAQSI IGTASRVHML
     SSSPVRLAWQ THYVGDLRAV NNELIDTYQL KSLDGLVEAR LEKIVIAERK DQSKRAPGGK
     KKAKRRQFYL MLKKYPQNSH DKNSSGVTQE ELSGYIIDNF PMRKPYDRVI RCLGFRFNFS
     IFDSSASPPN SENAKGRLPG ITAWYEGKDS PGLFVLGTAS HSRDYRASAG GFIHGFRYTA
     RAVHRVLEHR YHGNAWPSIN LSTTQLLSWI LKRISEASGP YQMFEVVGDV ILLQGPRCEY
     VEEFLLQALP QFSSLSGHQV SRHGFIVLVM QYGKKKIDYL GRGRAETDWT KAWKSNFLHP
     VLYYYDRLPT EEEMSMRPHG WPLPRPRAIH HMVEDFLTEW DGPLSHIQPL RHFLEHCVQT
     DLRAFYAESC FRAALTHRKP PLFCQQGYLN RQGLSRNTQL LQHVFDNGPP RPQHHDAGTS
     DANPAFPSYL APAGACLSSG LKLDF
//