ID H2MW36_ORYLA Unreviewed; 1845 AA.
AC H2MW36;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Plexin A3 {ECO:0000313|Ensembl:ENSORLP00000023051.2};
GN Name=plxna3 {ECO:0000313|Ensembl:ENSORLP00000023051.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000023051.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000023051.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000023051.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000023051.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000023051.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR Ensembl; ENSORLT00000023052.2; ENSORLP00000023051.2; ENSORLG00000018412.2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01050000244850; -.
DR HOGENOM; CLU_001436_2_0_1; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000018412; Expressed in animal zygote and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF32; PLEXIN-A3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1191..1217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..495
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1221..1263
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1845 AA; 207160 MW; 50EF8746518927F1 CRC64;
LRSVCIILSS FSVNLSSVFF NTSLTHLTIH RRTGEVFVGA VNRVIKLSPN LTELKSHETG
PVEDNDMCYP PPSMRNCAHG LVNLDNVNKL LLVDYTGNRL VACGSIWQGV CQFLRLEDLF
KLGEPHHRKE HYLSGAREAD GMAGVVVDED DWISDPAKKK PVKGSSRLFI GAAIDGKSEY
FPTLSSRKLV ADEENMDMFS LVYQDEFVSS QIKIPSDTLS TYPAFDIYYI YGFSSRTYVY
FLTLQLDTQL TQMDAGGEKF FTSKIVRLCS NDTLFYSYVE FPLGCTKDGV EYRLVQAAYK
QKPGRRLAQA LGLSEDDDIL FVVFSQGQKN RSNPPRETVL CLFTLYNINM AIREKIHSCY
RGEGKLSLSW LLNRELNCIP TPHQIGDDFC GLVLNQPLGG LRVIEGFPLY EDRTEGMGAV
AGYTYGEHTV VFVGTRSGQL KKIRVDGIPP PTQNALLYET VPVVEGKPIL RDMVFSPDHQ
HIYLLSDRQV SKLPVESCDQ YSSCPDCLGS GDPHCGWCVL FNKCSRKEAC SRWEEPQHFN
TRLDQCVHIS VSPSNMSVTS PPTQLSVQMQ NVPALSGGVS CVFEDLTETL GEVLSKGQVK
CTLPSFRDLP SDSHTHGERV VQLSLRSKET GLQFISTTIV YYNCSVLSSC TSCVSSLFPC
HWCKYRHICT NNLQDCSFQE GRVSNMEGCP QILPNTDILV PAGMVRPITL RARNLPQPQS
GQKNYECVFS IQGKVQRIPA VRYNSSCIQC QNTSYWYDGD EAGDLPVDFS VVWDGDFLID
KPAFMKALLY KCEAQRSSCG QCLKAPTAFE CGWCTESRKC LLRQHCPSPE QNWMHHGRHN
LRCSHPRITR IDPLTGPREG GTRVTIEGEN LGLQVKEIAQ VQVAGVRCNP VPVQYISAER
CVHVEDLSGS MEGGFVENVG QSPSFNRIRP AIGPVSGGTR LTVFGRHLDA GSSVVVSINK
EECLFVKRTN REIVCITPAS VSGTGSASIR LMIDRAEVTS LEVKYTYTED PTITSVEPNW
TILNGSTMIT VMGTNLYTIQ EPKVRAKYGG LETTNFCTLV NDSAMTCLAP GLVYNKPEPP
DGALQPDEFG FIFDQVSSLL VLNSTPFMHY PNPTFDPLGN AGVLEGKNLI PGNNRLNYTV
LIGESPCVLT VSESQLLCDS PDLTGEQRVL ILVGGLEYSP GMLHIYSNSV LTLPAIIGIG
AGGGVLLIAI IAVLIAYKRK TRDADRTLKR LQLQMDNLES RVALECKEAF AELQTDIQEL
TNDMDGVKIP FLEYRTYTMR VMFPGIEEHP VLKELDSPAN VEKALRLFSQ LLNNKMFLLT
FIHTLEAQRS FSMRDRGNVA SLLMAALQGR MEYATVVLKQ LLADLIEKNL ENRNHPKLLL
RRTESVAEKM LTNWFTFLLH RFLKECAGEP LFMLFCAIKQ QMEKGPIDAI TGEARYSLSE
DKLIRQQIDY KQLTLMCIPP EGEAGTEVPV KVLNCDTVTQ VKDKLLDAVY KGIPFSQRPQ
ADDMDLEWRQ GRLTRIILQD EDVTTKIESD WKRLNTLAHY QVTDGSVVAL VQKQVSAYNI
ANSFTFTRSL SRYESLLRTS SSPDSLRSRA PMITPDQETG TKLWHLVKNH EHDQREGDRG
SKMVSEIYLT RLLATKGTLQ KFVDDLFETV FSTAHRGSAL PLAIKYMFDF LDEQADKRQI
SDPDVRHTWK SNCLPLRFWV NVIKNPQFVF DIHKNSITDA CLSVVAQTFM DSCSTSEHRL
GKDSPSNKLL YAKDIPNYKS WVERYYRDIT KMPSISDQDM DAYLVEQSRL HGNEFNTLSA
LNELYFYINK YKEEILTALD RDGYCRKHKL RHKLEQAINL MAGSS
//
