ID H2N025_ORYLA Unreviewed; 1234 AA.
AC H2N025;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Son of sevenless homolog 1 (Drosophila) {ECO:0000313|Ensembl:ENSORLP00000024711.2};
GN Name=sos1 {ECO:0000313|Ensembl:ENSORLP00000024711.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000024711.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000024711.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024711.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000024711.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024711.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2N025; -.
DR Ensembl; ENSORLT00000024712.2; ENSORLP00000024711.2; ENSORLG00000019899.2.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000155423; -.
DR HOGENOM; CLU_002744_1_0_1; -.
DR TreeFam; TF317296; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000019899; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF168; SON OF SEVENLESS HOMOLOG 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00414; H2A; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 200..390
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 443..548
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 599..741
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 780..1019
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1033..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1234 AA; 141282 MW; FA752EF603A2EA7C CRC64;
MQTGQLQFDF CSEDNAPRWR GLLVPSLEKV LNQVHPNLKS QQEALQYIEE LILLLLSMLC
QAQPRTVQDV EERVQKSFPY PIDKWAIADA QAAIEKRKRR NPLSLPVDKI HPLLKEVLGY
KIEHQVSVYM VAVLEYISAD ILKLAGNYVR NIRHYDITKQ DITVAMCADK VLMDMFHQDD
EDPTGFPLID EEPSANEDQS YLELVRSFMA DGRQYLRQLN LIIKVFREPL SSCPMLFSQH
EVDSIFSRIL DIHEVTMKLL GLIEDAVEMT DEGSPHPLVG SCFEDLAEEL AFDPYETYSQ
DVLRSGFQEH FLSQVSKPGA SFHLQSICEG FKEAVQYVLP RLLLTPVYHC LHLFDILKQL
EEKSEDEEDK ECLKQAITAL LNLQSSMERI CSRNLAKRRL SESACRLYSH QMKGKHLAIK
KMNEIQKNID GWEGKDIGQS CNEFIMEGTL TRVGAKHERH IFLFDGLMVC CKSNHGPPRL
PGTSSAAEYR LKEKFFMRKI QINDKDDKEG EYRHAFEIIL KDGNSVVFAA KSAEEKNSWM
AALVSLQYRS TLERMLDTAM MQEEKQEQMR LPGAEEYRFA EPDSEENVVF EENVQSRSGI
PIIKAGTVLK LIERLTFHMY ADPNFVRTFL TTYRSFCKPQ ELLDLLIERF EIPEPRPAEA
DPTEGGDQLL SAELKRFRKE FVQPVQLRVL NVCRHWVEHH FYDFERDIHL LGQLEDFIAS
VRGKAMRKWV ESITKIIQRK KQVQVSLPSH SITFQNSPPP IEWHICKPGN SEHFDLMTLH
PIEIARQLTL LESDFYRAVQ PSELVGSVWT KEDKEIHSPN LLRMIRHTTN LTLWLEKCIV
EAENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQRRI
LEEAHELSED HYKKYLMKLR SINPPCVPFF GIYLTNILKT EEGNPDFLRR HGKDLINFSK
RRKVAEITGE IQQYQNQPYC LRVESEIRKF LENLNPMGDL SEKDFADYLF NKSLEIEPRN
TRSLPRFAKR YTCPLKSPGI RPTSTRPGTM RHPTPLQNEP RKISYSRIPD SEAEGGAVSA
PNSPRTPLTP PPASAASSST DVGSVFDSPQ GPSSPFHSTC DSIFAVISLP RGPRSSSVSS
IVSFSRGSED APVPPPVPPR RRPESAPSES SPSKALSEPQ RSIARLVAFI SVCEPGPCDH
WTSVETDQNR RGAVMVLVDL FVFVVLMNEL DVCL
//
