ID H2N1E8_ORYLA Unreviewed; 363 AA.
AC H2N1E8; H2N1E7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Urotensin-2 receptor {ECO:0000256|ARBA:ARBA00014302};
DE AltName: Full=Urotensin II receptor {ECO:0000256|ARBA:ARBA00032764};
GN Name=uts2r {ECO:0000313|Ensembl:ENSORLP00000025250.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025250.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000025250.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025250.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025250.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025250.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The
CC activity of this receptor is mediated by a G-protein that activate a
CC phosphatidylinositol-calcium second messenger system.
CC {ECO:0000256|ARBA:ARBA00025579}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_011471784.1; XM_011473482.1.
DR RefSeq; XP_011471785.1; XM_011473483.1.
DR STRING; 8090.ENSORLP00000040984; -.
DR Ensembl; ENSORLT00000025250.2; ENSORLP00000025249.2; ENSORLG00000020371.2.
DR Ensembl; ENSORLT00000025251.2; ENSORLP00000025250.2; ENSORLG00000020371.2.
DR Ensembl; ENSORLT00000028862.1; ENSORLP00000040984.1; ENSORLG00000020371.2.
DR GeneID; 101160888; -.
DR CTD; 2837; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01090000260051; -.
DR HOGENOM; CLU_009579_1_0_1; -.
DR OrthoDB; 5389384at2759; -.
DR TreeFam; TF334200; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000020371; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001604; F:urotensin II receptor activity; IBA:GO_Central.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR CDD; cd14999; 7tmA_UII-R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000670; Urot_II_rcpt.
DR PANTHER; PTHR24230; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24230:SF60; UROTENSIN-2 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00647; UROTENSIN2R.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..299
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 363 AA; 41170 MW; 48A15859BFEAF915 CRC64;
MTTMSMEPVG VLVERATNAT APPLSSLEDS AATFTIGTIL SIMCLVGVSG NIYTLVVMCH
SMRAAASMYI YIINLAMADL LYLLTIPFVV CTHFLKGWYF GDAGCRILIS MDFLTMHASI
FTLTIMSTER YFAVLKPLDT VKRSKSYRKA IALLVWAASL ILTLPMIVSI QLMTVGTKAM
CHSTLSPLSY KVYISFLFCT SIVAPGLIIG FLYIQLARTY WISQTETFKQ TKKLPNQKVL
YLIFTIVLLF WACFLPFWIW QLLGQFYPSL PLSTKAKCNI NYLTTCLTYS NSCINPFLYT
LLTKNYKEYL RKHKRSWTAG NYFNRRSRFQ RSPRRSPSAS SQQCTESFML THTASLRAHN
SSL
//
