ID H2N2H5_ORYLA Unreviewed; 530 AA.
AC H2N2H5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN Name=depdc1b {ECO:0000313|Ensembl:ENSORLP00000025663.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025663.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000025663.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025663.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025663.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025663.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011471605.1; XM_011473303.1.
DR AlphaFoldDB; H2N2H5; -.
DR STRING; 8090.ENSORLP00000025663; -.
DR Ensembl; ENSORLT00000025664.2; ENSORLP00000025663.2; ENSORLG00000020724.2.
DR GeneID; 101173206; -.
DR KEGG; ola:101173206; -.
DR CTD; 55789; -.
DR eggNOG; ENOG502QR00; Eukaryota.
DR GeneTree; ENSGT00950000182976; -.
DR HOGENOM; CLU_040757_0_0_1; -.
DR InParanoid; H2N2H5; -.
DR OrthoDB; 5405142at2759; -.
DR TreeFam; TF328365; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000020724; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04405; RhoGAP_BRCC3-like; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR16206; DEP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR16206:SF11; DEP DOMAIN-CONTAINING PROTEIN 1B; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 195..396
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 530 AA; 61423 MW; C04BB49CBAF0C25F CRC64;
MEGEVIGPGP YRATKLWNET IKLFRGGMPV RRHWAHFRCY DWSFSGSEAV DYLHQLLRSN
SNFGPEVTRY QTLQLLKKFF KAHVIEDVKG RYGTEDFEDG GQLYRFPTMS PLKTLPTRPL
VRDSRDLPRL IRWDDYEELP LQENVAPSKS AVLASDLWNK RHSVAIGDVN ECKLIRRKEV
TQKQVDHIWK TMTVTHLQKV LGLKTLDGVL NPVHVNGRHI VHNVFSVNKT GIVVLENKSE
DMPYWVVSAM KCLANWPNSN DSKQPLYPSF ERDVLRTIVD YFQRLKEPLL TFHLYEVFVS
ILGLLQEKDT ATEALQISCL LLPPPNRRRL QLLLRLMARV CHNPLLPPLN DTIATHTLMV
HLFSPCVLGS ADDMDLDELL ATKLVTFMME HHNNIFHVNR KLRCQVEEHL SHLKRAQIKY
VGSDTDFSSS PAFCKHISKV DSEEQKVIGT QIPLQQLLEG LIADKELTVK DKRKRLKQFQ
KSYPEVYRNR FPTEESKAAV IPEKSSRFRP PLTFLKKPLQ PFQRSWSFRA
//
