ID H2N3G7_PONAB Unreviewed; 664 AA.
AC H2N3G7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000000138.2};
GN Name=TRIM11 {ECO:0000313|Ensembl:ENSPPYP00000000138.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000138.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000138.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000000138.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2N3G7; -.
DR Ensembl; ENSPPYT00000000149.2; ENSPPYP00000000138.2; ENSPPYG00000000138.2.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160371; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; H2N3G7; -.
DR OMA; RECIGRC; -.
DR TreeFam; TF338674; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0046597; P:negative regulation of viral entry into host cell; IEA:Ensembl.
DR GO; GO:0032897; P:negative regulation of viral transcription; IEA:Ensembl.
DR GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
DR GO; GO:0044790; P:suppression of viral release by host; IEA:Ensembl.
DR CDD; cd19766; Bbox2_TRIM11_C-IV; 1.
DR CDD; cd16594; RING-HC_TRIM7-like_C-IV; 1.
DR CDD; cd15811; SPRY_PRY_TRIM11; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF648; E3 UBIQUITIN-PROTEIN LIGASE TRIM11; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 212..253
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 283..324
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 464..657
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 120..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 325..402
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 664 AA; 73629 MW; 1E0E0702FEA42E4F CRC64;
MPQAAGSLSP CSCFRVPRPK SPFLLALPPV PSLPCAPPPS PSLPCAGVLP RAGVKDLATR
TRAVGTPGQQ VKALQFRPAR GPRDWQRPIG GKSGLFQIKK KKHKTHPVAS CFRLGSSSCR
HPGSLRPASP ERPEPTRPAL PKLRVLRPGV PAPRSPSTRE SRACATAPGY PSSPRAPESA
RRRPADSTAF LPLVRAMAAP DLSTNLQEEA TCAICLDYFT DPVMTDCGHN FCRECIRRCW
GQPEGPYACP ECRELSPQRN LRPNRPLAKM AEMARRLHPP SPVPQGVCPA HREPLAAFCG
DELRLLCAAC ERSGEHWAHR VRPLQDAAED LKAKLEKSLE HLRKQMQDAL LFQAQADETC
VLWQKMVESQ RQNVLGEFER LRRLLAEEEQ QLLQRLEEEE LEVLPRLREG AARLGQQSAH
LAELIAELEG RCQLPALGLL QDIKDALRRV QDVKLQPPEV VPMELRTVCR VPGLVETLRR
FRGDVTLDPD TANPELILSE DRRSVQRGDL RQALPDSPER FDPGPCVLGQ ERFTSGRHYW
EVEVGDRTSW ALGVCRENVN RKEKGELSAG NGFWILVFLG SYYNSSERAL APLRDPPRRV
GIFLDYEAGH LSFYSATDGS LLFIFPEIPF SGTLRPLFSP LSSSPTPMTI CRPKGGSGDT
LAPQ
//
