ID H2NAH8_PONAB Unreviewed; 543 AA.
AC H2NAH8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=SAM domain-containing protein {ECO:0000259|PROSITE:PS50105};
GN Name=SAMD8 {ECO:0000313|Ensembl:ENSPPYP00000002689.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000002689.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000002689.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000002689.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR AlphaFoldDB; H2NAH8; -.
DR Ensembl; ENSPPYT00000002780.3; ENSPPYP00000002689.2; ENSPPYG00000002315.3.
DR eggNOG; KOG3058; Eukaryota.
DR GeneTree; ENSGT00940000155540; -.
DR HOGENOM; CLU_027104_1_1_1; -.
DR InParanoid; H2NAH8; -.
DR OMA; GADWLCN; -.
DR TreeFam; TF314547; -.
DR Proteomes; UP000001595; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002950; F:ceramide phosphoethanolamine synthase activity; IEA:Ensembl.
DR GO; GO:0046513; P:ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:1905373; P:ceramide phosphoethanolamine biosynthetic process; IEA:Ensembl.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 281..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..206
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..50
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 61195 MW; 0AEA5F8C780F2059 CRC64;
MRPRAPPRQH LGSPLGPIWS LASFPAWAPP PAGRTPSPAG RAPPPEAVPV RLTGPAGAAV
TAAGTMPARS RHRPRLHSGS PPQAPPPPLE ALHSGEAGRA PDSDGGSDAD SEVGPGSPTR
TAEAAEEEMA GPNQLCIRRW TTKHVAVWLK DEGFFEYVDI LCNKHRLDGI TLLTLTEYDL
RSPPLEIKVL GDIKRLMLSV RKLQKIHIDV LEEMGYNSDS PIGSMTPFIS ALQSTDWLCN
GELSHDCDGP ITDLNSDQYQ YMNGKNKHSV RRLDPEYWKT ILSCIYVFIV FGFTSFIMVI
VHERVPDMQT YPPLPDIFLD SVPRIPWAFA MTEVCGMILC YIWLLVLLLH KHRSILLRRL
CSLMGTVFLL RCFTMFVTSL SVPGQHLQCT GKIYGSVWEK LHRAFAIWSG FGMTLTGVHT
CGDYMFSGHT VVLTMLNFFV TEYTPRSWNF LHTLSWVLNL FGIFFILAAH EHYSIDVFIA
FYITTRLFLY YHTLANTRAY QQSRRARIWF PMFSFFECNV NGTVPNEYCW PFSKPAIMKR
LIG
//
