ID H2NJ34_PONAB Unreviewed; 1156 AA.
AC H2NJ34; A0A2J8XIY5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX37 {ECO:0000313|Ensembl:ENSPPYP00000005819.3};
GN ORFNames=CR201_G0000739 {ECO:0000313|EMBL:PNJ81961.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000005819.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000005819.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ81961.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ81961.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000005819.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; NDHI03003364; PNJ81961.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000005819; -.
DR Ensembl; ENSPPYT00000006042.3; ENSPPYP00000005819.3; ENSPPYG00000005106.3.
DR eggNOG; KOG0926; Eukaryota.
DR GeneTree; ENSGT00550000074985; -.
DR HOGENOM; CLU_001832_0_0_1; -.
DR OMA; KYAYHCA; -.
DR TreeFam; TF105654; -.
DR Proteomes; UP000001595; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:2000020; P:positive regulation of male gonad development; IEA:Ensembl.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR GO; GO:0042255; P:ribosome assembly; IEA:Ensembl.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 261..428
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 547..715
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..221
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..576
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 129459 MW; 19CE1326ACEBCD18 CRC64;
MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK
APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL SEVQASEAEM RLFYTTSKLG
TGDRMYHTKE KPDEVVAPGQ EKISSLSGAH RKRRRWPSAE EEEEEEESES ELEEESELAE
DPAAEPAEAG MGTTVAPLPP APAPSSQPVL AGMSVPPPPA AAPPLPRALA KPAVFIPVNR
SPEMQEERLK LPILSEEQVI MEAVAEHPIV IVCGETGSGK TTQVPQFLYE AGYSSEDSII
GVTEPRRVAA MAMSQRVAKE MNLSQRVVSY QIRYEGNVTE ETRIKFMTDG VLLKEIQKDF
LLLRYKVVII DEAHERSVYT DILIGLLSRI VTLRAKRNLP LKLLIMSATL RVEDFTQNSR
LFAKPPPVIK VESRQFPVTV HFNKRTPLED YSGECFRKVC KIHRMLPAGG ILVFLTGQAE
VHALCRRLRK AFPPSRARPQ EKDDDQKDSA EEMRKFKKSR ARAKKARAEV LPQINLDHYS
VLPAGEGDED REAEVDEEEG ALDSDLDLDL GDGGQDEGEQ PDASLPLHVL PLYSLLAPEK
QAQVFKPPPE GTRLCVVATN VAETSLTIPG IKYVVDCGKV KKRYYDRVTG VSSFHVTWVS
QASADQRAGR AGRTEPGHCY RLYSSAVFGD FEQFPPPEIT RRPVEDLILQ MKALNIEKVI
NFPFPTPPSM EALLAAEELL IALGALQPPQ KAERVKQLQK NRLSCPITAL GRTMATFPVA
PRYAKMLALS RQHGCLPYAI TIVASMTVRE LFEELDRPAA SDEELARLKS KRARVAQMKR
TWAGQGASLK LGDLMVLLGA VGACEYAGCT PQFCEANGLR YKAMMEIRRL RGQLTTAVNA
VCPEAELFVD PKMQPPTESQ VTYLRQIVTA GLGDHLARRV QSEELLEDKW RNAYKTPLLD
DPVFIHPSSV LFKELPEFVV YQEIVETTKM YMKGVSSVEV QWIPALLPSY CQFDKPLEEP
APTYCHERGR VLCHRASVFY RVGWPLPAIE VDFPEGIDRY KHFARFLLEG QVFRKLSSYQ
SCLLSSPGTM LKTWARLQPR TESLLRALVA EKADCHEALL AAWKKNPKYL LAEYCEWLPQ
AVHPDIEKAW PPTTVH
//
