ID H2NV06_PONAB Unreviewed; 1370 AA.
AC H2NV06;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Apoptosis associated tyrosine kinase {ECO:0000313|Ensembl:ENSPPYP00000009797.2};
GN Name=AATK {ECO:0000313|Ensembl:ENSPPYP00000009797.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009797.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000009797.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000009797.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2NV06; -.
DR Ensembl; ENSPPYT00000010188.2; ENSPPYP00000009797.2; ENSPPYG00000008728.2.
DR eggNOG; ENOG502RCHK; Eukaryota.
DR GeneTree; ENSGT00940000154244; -.
DR HOGENOM; CLU_004618_1_0_1; -.
DR InParanoid; H2NV06; -.
DR OMA; MACEVSC; -.
DR TreeFam; TF332280; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR CDD; cd05087; PTKc_Aatyk1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042817; LMTK1_c.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24417; SERINE/THREONINE-PROTEIN KINASE LMTK1; 1.
DR PANTHER; PTHR24417:SF0; SERINE_THREONINE-PROTEIN KINASE LMTK1; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 125..395
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 542..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1089
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1169
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1332
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 156
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1370 AA; 144079 MW; 5D43A04C71D9C1F7 CRC64;
MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI
GFKEFENAEG DEYVADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDL
GRHSLLYLKE IGHGWFGKVF LGEVNSGVSS AQVVVKELQA SASVQEQMQF LEEAQPYRAL
KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPLTL QRMACEVACG
ILHLHRNNYV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE
LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYA VREQQLKLPK
PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG
GGSVGPGPGA VGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK
WEAGRGAEAF PATLSPGRTA RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA
AGHDPDCAGC APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA
RDPLCPSPSP SPGPLRLAEG EAEDADWGVA AFCPPFFEDP LGTSPLGSSG ALPLTGEDEL
EEVGARRAAQ RGHWRSNVSA NNNSGSRCPE SWDPSSAGCH AEDCPSPKQT PRASPEPGYP
GEPLLGLQAP SAQEPGCCPG LPHPCPAQGL APAPCLVTPS WTETAGSGGD HPQAEPKLAT
EAEGTAGPCL PLPSVPSPSQ EGAPLPSEEA SAPDAPDALP DSPTPATGGE VSATKLASAL
NGSSSSPEVE APSSEDEDTA EATSGIFTDT SSDGLQAERP DVVPAFRSLQ KQVGTPDSVD
SLDIPSSASD GGYEVFSPSA AGPSGGQPRA LDSGYDTENY ESPEFVLKEA QEGCEPQAFA
ELASEVEGTG PETRLSTSPS GLNEKNPYRD SAYFSDLEAE AEPTSGPEKK CGGDQAPGPG
LDLPSTGQPS EQASLSPGVS GEAQGSGPGE VLPPLLRLEG SSPEPSTCPS GLGPEPPEPQ
GPAEVPPGPS PSCSQFFLLT PVPLRSEGNS SEFQGPPGLL SGPAPQKRMG GPGTPRAPLR
LALPGLPAAL EGRPEEEEED SEDSDESDEE LRCYSVQEPS EDSEEEAPAV PVVVAESQSA
RNLRSLLKMP SLLSEAFCED LERKKKAVSF FDDVTVYLFD QESPTRELGE PFPGAKESPP
TFLTGSPGSP SAPNRPQQAD GSPDGSTAEE GGGFAWDDDF PPMPAKAAFA MALDPATPAP
AAPTPTPAPF SRFTVSPAPT SRFSITHVSD LDAESMRGPE AGAEGDSKEA
//
