ID H2NWK9_PONAB Unreviewed; 506 AA.
AC H2NWK9; A0A2J8T7S9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=CNDP1 isoform 2 {ECO:0000313|EMBL:PNJ29062.1};
DE SubName: Full=Carnosine dipeptidase 1 {ECO:0000313|Ensembl:ENSPPYP00000010374.3};
GN Name=CNDP1 {ECO:0000313|Ensembl:ENSPPYP00000010374.3};
GN ORFNames=CR201_G0037272 {ECO:0000313|EMBL:PNJ29062.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000010374.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000010374.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ29062.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ29062.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000010374.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRSR:PIRSR037242-3};
CC Note=Binds 2 manganese ions per subunit.
CC {ECO:0000256|PIRSR:PIRSR037242-3};
CC -!- SIMILARITY: Belongs to the peptidase M20A family.
CC {ECO:0000256|ARBA:ARBA00006247}.
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DR EMBL; NDHI03003518; PNJ29062.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000010374; -.
DR Ensembl; ENSPPYT00000010786.3; ENSPPYP00000010374.3; ENSPPYG00000009244.3.
DR eggNOG; KOG2276; Eukaryota.
DR GeneTree; ENSGT00940000160484; -.
DR HOGENOM; CLU_029469_3_1_1; -.
DR OMA; CKGNIVM; -.
DR OrthoDB; 177966at2759; -.
DR TreeFam; TF300633; -.
DR Proteomes; UP000001595; Chromosome 18.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070573; F:metallodipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR GO; GO:0051246; P:regulation of protein metabolic process; IEA:Ensembl.
DR CDD; cd05676; M20_dipept_like_CNDP; 1.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR017153; CNDP/DUG1.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR PANTHER; PTHR43270; BETA-ALA-HIS DIPEPTIDASE; 1.
DR PANTHER; PTHR43270:SF1; BETA-ALA-HIS DIPEPTIDASE; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR PIRSF; PIRSF037242; CNDP_dipeptidase; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00759; ARGE_DAPE_CPG2_2; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|PIRSR:PIRSR037242-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR037242-3};
KW Protease {ECO:0000256|ARBA:ARBA00022645};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..506
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041198975"
FT DOMAIN 241..398
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
FT ACT_SITE 133
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-1"
FT ACT_SITE 198
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-1"
FT BINDING 131
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT BINDING 164
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT BINDING 164
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT BINDING 199
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT BINDING 227
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT BINDING 477
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-3"
FT SITE 260
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR037242-4"
SQ SEQUENCE 506 AA; 56509 MW; AF819B7C468E62E3 CRC64;
MDPKLGRMAA SLLAVLLLLE GGMFSSPSPP PVLLEKVFQY IDLHQDDFVQ MLKEWVAIES
DSVQPVPRFR QELFRMMAMA ADTLQRLGAR VASVDMGPQQ LPNGQSLPIP PVILAELGSD
PTKGTVCFYG HLDVQPADRG DGWLTDPYVL TEVEGKLYGR GATDNKGPVL AWINAVSAFR
ALEQDLPVNI KFIIEGMEEA GSVALEELVE KEKDRFFSGV DYIVISDNLW ISQRKPAITY
GTRGNSYFTV EVKCRDQDFH SGTFGGILHE PMADLVALLG SLVDSSGHIL VPGIYDEVAP
LTEEEINTYK AIHLDLEEYR NSSRVEKFLF DTKEEILMHL WRYPSLSIHG IEGAFDEPGA
KTVIPGRVIG KFSIRLVPHM NVSVVEKQVT RHLEDVFSKR NSSNKMVVSM TLGLHPWIAN
INDTQYLAAK RAIRTVFGTE PDMIRDGSTI PIAEMFQEIV HKSVVLIPLG AVDDGEHSQN
EKINRWNYIE GTKLFAAFFL EMAQLH
//
