ID H2NYE9_PONAB Unreviewed; 161 AA.
AC H2NYE9; A0A2J8RRA5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN Name=FXYD5 {ECO:0000313|Ensembl:ENSPPYP00000011030.3};
GN ORFNames=CR201_G0049100 {ECO:0000313|EMBL:PNJ11050.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011030.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011030.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ11050.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ11050.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000011030.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000256|ARBA:ARBA00005948,
CC ECO:0000256|RuleBase:RU364131}.
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DR EMBL; NDHI03003659; PNJ11050.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000011461.3; ENSPPYP00000011030.3; ENSPPYG00000009852.3.
DR eggNOG; ENOG502SA05; Eukaryota.
DR GeneTree; ENSGT00940000153062; -.
DR HOGENOM; CLU_109413_0_0_1; -.
DR OMA; PRLCRNY; -.
DR TreeFam; TF338182; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of monoatomic ion transport; IEA:InterPro.
DR CDD; cd20323; FXYD_FXYD5; 1.
DR Gene3D; 1.20.5.780; Single helix bin; 1.
DR InterPro; IPR047297; FXYD_motif.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR PANTHER; PTHR14132:SF14; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5; 1.
DR PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU364131};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364131};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|RuleBase:RU364131};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364131};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364131};
KW Transport {ECO:0000256|RuleBase:RU364131}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT CHAIN 22..161
FT /note="FXYD domain-containing ion transport regulator"
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT /id="PRO_5041477114"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT REGION 41..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 161 AA; 17524 MW; 3181BE0413ED9E5C CRC64;
MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSANSTIMDI QVPTPAPETP QPQTQTQTQR
PAGTDGPLVT DPETHKSTKA AHPTDDTTTL SERPSPSTDV QTDPQTLKPS GFREDDPFFY
DEHTLRKRGL LVAAVLFITG IIILTSGKCR QLSRLCRNHC R
//
