ID   H2NZA4_PONAB            Unreviewed;       492 AA.
AC   H2NZA4; A0A2J8U6R5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=NOVA alternative splicing regulator 2 {ECO:0000313|Ensembl:ENSPPYP00000011339.3};
DE   SubName: Full=NOVA2 isoform 1 {ECO:0000313|EMBL:PNJ40964.1};
GN   Name=NOVA2 {ECO:0000313|Ensembl:ENSPPYP00000011339.3};
GN   ORFNames=CR201_G0029436 {ECO:0000313|EMBL:PNJ40964.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011339.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000011339.3, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ40964.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ40964.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000011339.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Interacts with PTBP2; the interaction is direct.
CC       {ECO:0000256|ARBA:ARBA00034798}.
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DR   EMBL; NDHI03003467; PNJ40964.1; -; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000011339; -.
DR   Ensembl; ENSPPYT00000011780.3; ENSPPYP00000011339.3; ENSPPYG00000010139.3.
DR   eggNOG; KOG2191; Eukaryota.
DR   GeneTree; ENSGT00940000161740; -.
DR   HOGENOM; CLU_022670_1_1_1; -.
DR   OMA; TERICLI; -.
DR   OrthoDB; 5478127at2759; -.
DR   TreeFam; TF316981; -.
DR   Proteomes; UP000001595; Chromosome 19.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IEA:Ensembl.
DR   GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR   GO; GO:1902667; P:regulation of axon guidance; IEA:Ensembl.
DR   CDD; cd22435; KH-I_NOVA_rpt1; 1.
DR   CDD; cd22436; KH-I_NOVA_rpt2; 1.
DR   CDD; cd09031; KH-I_NOVA_rpt3; 1.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 3.
DR   InterPro; IPR047275; KH-I_NOVA_rpt1.
DR   InterPro; IPR047276; KH-I_NOVA_rpt2.
DR   InterPro; IPR047274; KH-I_NOVA_rpt3.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR   PANTHER; PTHR10288:SF162; RNA-BINDING PROTEIN NOVA-2; 1.
DR   Pfam; PF00013; KH_1; 3.
DR   SMART; SM00322; KH; 3.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR   PROSITE; PS50084; KH_TYPE_1; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00117}.
FT   DOMAIN          31..104
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
FT   DOMAIN          129..201
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
FT   DOMAIN          405..478
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
SQ   SEQUENCE   492 AA;  49009 MW;  41B63EAF6899256B CRC64;
     MEPEAPDSRK RPLETPPEVV CTKRSNTGEE GEYFLKVLIP SYAAGSIIGK GGQTIVQLQK
     ETGATIKLSK SKDFYPGTTE RVCLVQGTAE ALNAVHSFIA EKVREIPQAM TKPEVVNILQ
     PQTTMNPDRA KQAKLIVPNS TAGLIIGKGG ATVKAVMEQS GAWVQLSQKP EGINLQERVV
     TVSGEPEQVH KAVSAIVQKV QEDPQSSSCL NISYANVAGP VANSNPTGSP YASPADVLPA
     AAAASAAAAS GLLGPAGLAG VGAFPAALPA FSGTDLLAIS TALNTLASYG YNTNSLGLGL
     NSAAASGVLA AVAAGANPAA AAAANLLASY AGEAGAGPAG GAAPPPPPPP GALGSFALAA
     AANGYLGAGA GGGAGGGGGP LVAAAAAAGA AGGFLTAEKL AAESAKELVE IAVPENLVGA
     ILGKGGKTLV EYQELTGARI QISKKGEFLP GTRNRRVTIT GSPAATQAAQ YLISQRVTYE
     QGVRASNPQK VG
//