ID H2P2I7_PONAB Unreviewed; 481 AA.
AC H2P2I7; A0A2J8RBA3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=CABLES2 isoform 1 {ECO:0000313|EMBL:PNJ05785.1};
DE SubName: Full=Cdk5 and Abl enzyme substrate 2 {ECO:0000313|Ensembl:ENSPPYP00000012521.3};
GN Name=CABLES2 {ECO:0000313|Ensembl:ENSPPYP00000012521.3};
GN ORFNames=CR201_G0052232 {ECO:0000313|EMBL:PNJ05785.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000012521.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000012521.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ05785.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ05785.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000012521.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003717; PNJ05785.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000012521; -.
DR Ensembl; ENSPPYT00000013014.3; ENSPPYP00000012521.3; ENSPPYG00000011206.3.
DR eggNOG; KOG4164; Eukaryota.
DR GeneTree; ENSGT00400000022086; -.
DR HOGENOM; CLU_021942_2_1_1; -.
DR OMA; CRTKHIS; -.
DR OrthoDB; 209340at2759; -.
DR TreeFam; TF323936; -.
DR Proteomes; UP000001595; Chromosome 20.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd20603; CYCLIN_CABLES2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR012388; CABLES1/2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR22896; CDK5 AND ABL1 ENZYME SUBSTRATE 1; 1.
DR PANTHER; PTHR22896:SF3; CDK5 AND ABL1 ENZYME SUBSTRATE 2; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF025798; Cables; 2.
DR SUPFAM; SSF47954; Cyclin-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 372..462
FT /note="Cyclin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00134"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..97
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 52574 MW; 0428CDABB9324F3C CRC64;
MAAAAAGGAP GPVPSPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF FLNNISLDGR
PPSLGPGGEK PPPPPAEARE PPAPPPPETP AGLPGLPVRT PAPQGLLSPT QVPAGLGLDG
QRQRKRVTSQ RCSLEFLEDA VGCAPAQRTK HTSGSPRHKG LKKTHFIKNM RQYDTRNSRI
VLICAKRSLC AAFSVLPYGE GLRLSDLRVD SQKQRHPSGG ISVSSEMVFE LEGVELGADG
KVVSYAKFLY PTNALVTHKS DSHGLLPTPR PSVPRTLPGS RHKPAPTKSA PASTELGSDV
GDTLEYNPNL LDDPQWPCGK HKRVLIFASY MTTVIEYVKP SDLKKDMNET FREKFPHVKL
TLSKIRSLKR EMRSLSEECS LEPVTVAMAY VYFEKLVLQG KLSKQNRKLC AGACVLLAAK
ISSDLRKSGV KQLIDKLEER FRFNRRDLIG FEFTVLVALE LALYLPENQV LPHYRRLTQQ
F
//
