ID H2P369_PONAB Unreviewed; 715 AA.
AC H2P369; A0A2J8UAT5; A0A663DCF3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Interferon-induced GTP-binding protein Mx2 {ECO:0000256|ARBA:ARBA00039835};
DE AltName: Full=Myxovirus resistance protein 2 {ECO:0000256|ARBA:ARBA00042030};
GN Name=MX2 {ECO:0000313|Ensembl:ENSPPYP00000012763.1};
GN ORFNames=CR201_G0029326 {ECO:0000313|EMBL:PNJ42381.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000012763.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000012763.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ42381.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ42381.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000012763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; NDHI03003466; PNJ42381.1; -; Genomic_DNA.
DR RefSeq; XP_002830747.1; XM_002830701.1.
DR RefSeq; XP_009232257.1; XM_009233982.1.
DR STRING; 9601.ENSPPYP00000012763; -.
DR Ensembl; ENSPPYT00000013277.2; ENSPPYP00000012763.1; ENSPPYG00000011436.2.
DR GeneID; 100442884; -.
DR KEGG; pon:100442884; -.
DR CTD; 4600; -.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000163266; -.
DR HOGENOM; CLU_008964_8_0_1; -.
DR OMA; NFANFHN; -.
DR OrthoDB; 1052588at2759; -.
DR TreeFam; TF331484; -.
DR Proteomes; UP000001595; Chromosome 21.
DR GO; GO:0005643; C:nuclear pore; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0046822; P:regulation of nucleocytoplasmic transport; IEA:Ensembl.
DR GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF46; INTERFERON-INDUCED GTP-BINDING PROTEIN MX2; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 115..387
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 623..714
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
SQ SEQUENCE 715 AA; 82331 MW; 197313464798D8FD CRC64;
MSKAHKPWPY RRRNQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMVFPPNWQ GVEKDAAFLA
KDFNFLTLNN QPPLGNRSQP RAKGPENNLY SQYEQKVRPC IDLIDSLRAL GVEQDLALPA
IAVIGDQSSG KSSVLEALSG VALPRGSGIV TRCPLVLKLK KQPCEAWAGR ISYRNTELEL
QDPGQVEKEI HKAQNIMAGN GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD
IGLQIKALIK KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD
KGTEKSVMNV VRNLTYPLKK GYMIVRCRGQ QELTNRLSLA EATKKEITFF QTHPYFRVLL
EEGSATVPRL AERLTSELIM HIQKSLPLLE EQIRESHQKA TEELRRCGAD IPSQEADKMF
FLIEKIKMFN QDIEKLVEGE EAVRENETRL YNKIREDFKN WVGILATNTQ KVKNIIHEEV
EKYEKQYRGK ELLGFVNYKT FEFIVHQYIQ QLVEPALSML QKAVEIIRQA FINMAKKHFG
EFFNLNQTVQ SKIEDIKVKH TEKAENMIQL QFRMEQMVFC QDQIYSVILK KVREEIFNPL
GKPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFSETSKR LANQIPFIIQ YFMLRENGDS
LQKAMMQILQ EKNRYSWLLQ EQSETTTKRR ILKERIYRLT QARHALCQFS GKEIH
//
