ID H2P562_PONAB Unreviewed; 1294 AA.
AC H2P562; A0A2J8RJB1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=VWA3B isoform 6 {ECO:0000313|EMBL:PNJ08606.1};
DE SubName: Full=von Willebrand factor A domain containing 3B {ECO:0000313|Ensembl:ENSPPYP00000013471.2};
GN Name=VWA3B {ECO:0000313|Ensembl:ENSPPYP00000013471.2};
GN ORFNames=CR201_G0050548 {ECO:0000313|EMBL:PNJ08606.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013471.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000013471.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ08606.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ08606.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000013471.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003686; PNJ08606.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000013471; -.
DR Ensembl; ENSPPYT00000014020.2; ENSPPYP00000013471.2; ENSPPYG00000012082.2.
DR eggNOG; ENOG502QV6D; Eukaryota.
DR GeneTree; ENSGT00940000157237; -.
DR HOGENOM; CLU_008285_0_0_1; -.
DR OMA; VIMDWWY; -.
DR OrthoDB; 5396918at2759; -.
DR TreeFam; TF328978; -.
DR Proteomes; UP000001595; Chromosome 2A.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR032770; DUF4537.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46785; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR PANTHER; PTHR46785:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR Pfam; PF15057; DUF4537; 1.
DR Pfam; PF13768; VWA_3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 508..684
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1294 AA; 145666 MW; BD160DEFD31E8DA1 CRC64;
MEKSGSSSTI SEQQLQRQEG WSNTKTDLAE QSLISSEKWL QLHGLKSNKL TLKQILSQIG
FPHCEDYVAS LGRPVASRYA DGLFPQLCRT EDGRVYNLTA KSELIYQFVE HLTQAVESYK
QRMDWLTSKS RQIFGVILEQ CVTIVLDFGG ILEGELDLCR EALTMVLQEQ VAHITKFNII
RVSQEPVKWQ ENATPVTKQS IATAVSWVEK LMVELTVSEA GRLDALLEAG RDKTIESIYY
FVVGDVPEES KELLLQRALE IPCPVYTVSF NARGEGTIAF LKDLSAKTHS RFHAFAERTE
CVEFPAFSTK DGDDVMTWNS RNLKGKLPPG AGVREDVFLV WREMEEACST LAQIQRLVAE
PPKPDVATVD CESETTSVEI ASNPEDTWDS KTWLQKYGLK AQKLSLYDVL ADCSFRHADG
VVDIKAKPEN ESVQTSAETN KKTVHAKYCS RFVHAPWKDG SLVHVNITKE KCKWYSERIH
TALAQIRRRI KWLQDGSQSL FGRLHNDCIY ILIDTSHSMK SKLDLVKDKI IQFIQEQLKY
KSKFNFVKFD GQAVAWREQL AEVNEDSLEQ AQSWIRDMKI GSSTNTLSAL KTAFADKETQ
AIYLLTDGRP DQPPETVIDQ VKLFQEIPIY TISFNYNDEI ANRFLKEVAA LTGGEFHFYN
FGCKDPTPPE AVQNEDLTLL VKEMEQGYRD LEKMQDLYSE SLIMDWWYNA EKDGDSKHQK
EICSMISTPE KCAKPQSDVD STQTSSLNML KGPWGLSDQK VQKKKVLHAE STKTSLLRSQ
MSSLRSSACS ERKDGLSNAS SRRTALSDKE MSILLAEEWL DDKSSEKVTR EGSQVYDHHS
SDVSSENWLK TYGLVAKKLT LMDALSVAAV PHSSTYVPVL DKHVMSKVFD EVFPLAHVCK
DTNKMTLINP QGAKLNIYKQ KVEQAIQSYE KHLNKIVWQA LSQEEKEKLD ANKPIQYLEN
KTVLNQALER LNWPISLKEL SMLESEILAG KMYIQQAMEL QEAAKKNYGD KAPGEQQKLQ
GNPTKKTKSK RPDPLKGQKV IARCDENGFY FPGVVKKCVS RTQALVGFSY GDTKVVSTSF
IMPVGGAMPC PLLQVGDYVF AKIAIPKGFD FYVPAIVIAL PNKHVATEKF YTVLKCNNRR
EFCPRSALIK ISQNKYALSC SHIKSLPIPE DPEVEDVEAR NSAFLFRPLK EADTQDSREP
RREKPRRKKR PAKQPLQQAA PSDSDGSSHG TSSHGSCRGT HPEPKTAHLH FPAAGRLGLS
SHAIIATPPP RAALPCTLQA THSSKGLRSV PETP
//
