ID H2PDA3_PONAB Unreviewed; 416 AA.
AC H2PDA3; A0A2J8TKZ5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Transmembrane protease serine {ECO:0000256|PIRNR:PIRNR037941};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR037941};
GN Name=TMPRSS11B {ECO:0000313|Ensembl:ENSPPYP00000016452.2};
GN ORFNames=CR201_G0034192 {ECO:0000313|EMBL:PNJ33711.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016452.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000016452.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ33711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ33711.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000016452.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family.
CC {ECO:0000256|PIRNR:PIRNR037941}.
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DR EMBL; NDHI03003492; PNJ33711.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000016452; -.
DR MEROPS; S01.365; -.
DR Ensembl; ENSPPYT00000017121.2; ENSPPYP00000016452.2; ENSPPYG00000014727.2.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000163500; -.
DR HOGENOM; CLU_006842_19_0_1; -.
DR OMA; ADACQND; -.
DR OrthoDB; 4629979at2759; -.
DR TreeFam; TF351684; -.
DR Proteomes; UP000001595; Chromosome 4.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR017329; Pept_S1A_HAT/DESC1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF13; TRANSMEMBRANE SERINE PROTEASE 12; 1.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF037941; TMPRSS11ABCDE; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR037941};
KW Membrane {ECO:0000256|PIRNR:PIRNR037941, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|PIRNR:PIRNR037941};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Serine protease {ECO:0000256|PIRNR:PIRNR037941};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..160
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 185..415
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 225
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
FT ACT_SITE 270
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
FT ACT_SITE 366
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037941-1"
SQ SEQUENCE 416 AA; 46434 MW; 564C183D3A40519A CRC64;
MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD FHISGVTYND
NCENAASQAS TNLSKDTETK MLNAFQNSSI YKEYVKSEVI KLLPNANGSN VQLQLQFKFP
PAEKVSMRTK IKAILHQMLK NNMASWNAVP ASIKLMEISK AASEMLTNNC CGRQVANSII
NGNKIVNGKS SLMGAWPWQA SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF
GIVVNKPYMT RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTKYIRRIC LPEAKMKLSE
NDNVVVTGWG TLYMNGSFPV ILQEAFLKII DNKICNASYA YSGFVTDRML CAGFMSGEAD
ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY TRVTSYRNWI TSKTGL
//
