ID H2PF13_PONAB Unreviewed; 1612 AA.
AC H2PF13; A0A2J8XSD8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=PLEKHG4B isoform 1 {ECO:0000313|EMBL:PNJ84942.1};
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G4B {ECO:0000313|Ensembl:ENSPPYP00000017084.2};
GN Name=PLEKHG4B {ECO:0000313|Ensembl:ENSPPYP00000017084.2};
GN ORFNames=CR201_G0052366 {ECO:0000313|EMBL:PNJ84942.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017084.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000017084.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ84942.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ84942.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000017084.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003333; PNJ84942.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000017084; -.
DR Ensembl; ENSPPYT00000017777.2; ENSPPYP00000017084.2; ENSPPYG00000015294.2.
DR eggNOG; KOG0689; Eukaryota.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000162507; -.
DR HOGENOM; CLU_001356_2_2_1; -.
DR OMA; DLWLQCP; -.
DR TreeFam; TF334329; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF1; PLECKSTRIN HOMOLOGY AND RHOGEF DOMAIN CONTAINING G4B; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 1146..1325
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1337..1445
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 197..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1612 AA; 177296 MW; 795D1956B59A4A7D CRC64;
DLESLDAYIQ RTLSALYPPF EATAATVLWQ LFSVAERCHG GDGLHCLTSF LLPAKRALQH
LQQEACARYR GLVFLHPGWP LCAHEKVVVQ LASLHGVRLQ PGDFYLQVTS SGKQSARLVL
KCLSRLGRGT EEVTVPEAMY GCVFTGAFLE WVNRERRHVP LKTCLLTSGL AVHRAPWSDV
TDPVFVPSPG AILQSCSSCT GPERLPSSPS EAPVPTQAMA GPHFQGSTSC PDTLTPPCRQ
GRTGSDQLRH LPYPGRAELG SPRTLFGSSD RDFEKVSPSE QGPRMPPENC GGSGDRPDPM
DQEDGPKALT FHTDLGIPSS RRRPPGDPTC VQPRRWFRES YMEALRNPMP LGSSEEALRD
PACSSLAEAS WDLGTGAAAS GTQEETSGPR GDPQQTPSLE KERHTPSWTG PGAAGQTLPR
RSRSRERAPR SSRGAQAAAC HTSHHSAGSR PGGHRGGQAV GTPNCVPVEG PGCTKEEDVL
ASSACVSTDG GSLHCHNPSR PSGVPAQQPH PEQEGWPPGT GDFPSQVPKQ VLDVSQELLQ
SGIVTLPGTR DRHGRAVVQM HTRSPLWTRE HSSCAELTRL LLYFHSIPRK EVRDLGLVVL
VDARRSPAAP AVSHALAGLQ NNTSPIIHSI LLLVDKESAF RPDKDAIIQC EVVSSLKALH
KFVDSCQLTA DLDGSFPYSH GDWICFRQRL EHFAANCEEA IIFLQNSFCS LNTHRTPRTA
QEVTELIDQH ETMMKLVLED PLLVSLRLEG GTVLARLRRE ELGTEDSRDT LEASTGLYDR
VDEEVHRLVL ALNNRLQQLE RLRELASLLE GNDQQSYQKG LQLAKENPQR TEEMVQDFRR
GLSAVVSQAE CGEGELARWT HSSKLCETVS SWMGPLDPEA SASSLMAECL RSCHQEATSV
AAEAFPGAGV AVLKPHALGR LWASQQDLWL QYPQTRLRLE EALSKAAPDP SLLPLAQSPP
KHERAQEAMR RPHKPPSVPS TDSEGGAWEP AQPLSSLPGR ALLCGQDGEP LGPGLCAPWD
PLSPLRGLPG AGATTAHLED SSACSSEPTQ TLASRPRKHP QKKMIKKTQS FEIPQPDSGP
RDSCQPDHTG VFSKGLEVTS TVATEKKLLL RQRARSPPVT RSRSLSSPSG LHPAEEDGRQ
QVSSSRLRHI MAEMIATERE YVRCLGYVID NYFPEMKRMD LPQGLRGKHH VIFGNLEKLH
DFHQQHFLRE LERCRHCPLA VGRSFLRHEE QFGMYVIYSK NKPQSDALLS SHGNAFFKDK
QRELGDKMDL ASYLLRPVQR VAKYALLLQD LLKEASCSLA QGQELGELRA AEVMVCFQLR
HGNDLLAMDA IRGCDVNLKE QGQLRCRDEF IVCCGRKKYL RHVFLFEDLI LFSKTQKVEG
SHDVYLYKQS FKTAEIGMTE NVGDSGLRFE IWFRRRQKSQ DTYILQASSA EVKSAWTDVI
GRILWRQALK SRELRIQEMA SMGIGNQPFM DIKPRDRARD CAVISDRAPK CAVMSNRVPD
SIVKGTESQM RGSAAVSSSD HATPFKRPHS TISDSSTSSS SSQSSSILVS LGLLVSSSPA
HPGLWSPAHS PWSSDIRACV EEDEPEPELE TGTQAAVHEG APAVLLSRTR QA
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