ID H2PG36_PONAB Unreviewed; 1059 AA.
AC H2PG36; A0A2J8TD36;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=SLF1 isoform 1 {ECO:0000313|EMBL:PNJ30954.1};
DE SubName: Full=SMC5-SMC6 complex localization factor 1 {ECO:0000313|Ensembl:ENSPPYP00000017478.3};
GN Name=SLF1 {ECO:0000313|Ensembl:ENSPPYP00000017478.3};
GN ORFNames=CR201_G0035913 {ECO:0000313|EMBL:PNJ30954.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000017478.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000017478.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ30954.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ30954.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000017478.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003507; PNJ30954.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000017478; -.
DR Ensembl; ENSPPYT00000018186.3; ENSPPYP00000017478.3; ENSPPYG00000015634.3.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1929; Eukaryota.
DR GeneTree; ENSGT00940000158953; -.
DR HOGENOM; CLU_010529_0_0_1; -.
DR OMA; EMKNHDE; -.
DR OrthoDB; 2478587at2759; -.
DR TreeFam; TF329705; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0034184; P:positive regulation of maintenance of mitotic sister chromatid cohesion; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:1990166; P:protein localization to site of double-strand break; IEA:Ensembl.
DR CDD; cd17750; BRCT_SLF1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR042479; Slf1.
DR PANTHER; PTHR46677; SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1; 1.
DR PANTHER; PTHR46677:SF1; SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 2..80
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT DOMAIN 121..199
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT REPEAT 807..840
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 841..873
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 875..907
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 1059 AA; 121312 MW; 861C8713C599EB0F CRC64;
MEDGTPKHII QMTGFKMEEK EALVKLLLKL DCTFIKSEKY KNCTHLIAER LCKSEKFLAA
CAAGKWILTK DYIIHSAKSG RWLDETTYEW GYKIEKDSRY SPQMQSAPKR WREELKRTGA
PGAFHRWKVV LLVRTDKRSD SLIRVLEAGK ANVILPKSSP SGITHVIASN ARIKAEKEKD
NFKAPFYPIQ YLGDFLLEKE IQNDEDSQTN SVWTEHSNEE TNKDFRKDAG FLEMKGALRE
TMYRTQKEMQ NHDEDVNVGS ILTQHHKKEK FSGSSKDLKF VKMRNTFGRH TYENQKEIKK
KDEDIQRSYT LRRKRKKEKE SNCKKDIEHE KIKSTLRHIY NRDQKEMKNS IFAEYAKESK
AMAIKTDVDV VEIKNTLRKH IYRAQAVRYN CIRIDKQPVY NVEVKNAEFP RGVLNLIESL
IEGQFFKEAI EELSTLQARY IPPVCVLHAL LENVLQDNID TFSGRYFHIL SALLHLHPPW
KSPAMSRYYL ELFQCPTCMK GAWSLVEVLI RSCLFNESFC HQISENIGSK VLHLTLLKFF
FNLIESEVQH LSQKLYDWSD SQNLKITGKA MLLEIFWSGS ETSGLLTKPV NMLLEWTIYS
HKEKCKSNDV FKHELAYLLA GILGAAIDYW IFLGLKMGRN VMRHMSDDLG SYISLSCDDF
SSQELEIFIC SFSSSWLQMF VAEAVFKKLC LQSSGSVSSE PLSLQKMVYS YLPALGKTGV
LGSGKIQISK KIGQRPCFDS QRALLMLNGT KQKQVEGLPE LSDLNLAKCS SSSLKKLKKK
SEGELSCSKE NCPSVVKKMN FHKTNLKGET ALHRACINNQ VEKLILLLSL PGIDINVKDN
AGWTPLHEAC NYGNTVCVQE ILQRCPEVDL LTQVDGVTPL HDALSNGHVE IGKLLLQHGG
PVLLQQRNAK GELPLDYVVS PQIKEELFAI TEIEDTVENF HAQAEKHFHY QQLEFGSFLL
SRMLLNFCSI FDLSSEFILA SKGLTHLNEL LMACKSHKET TSVHTDWLLD LYAVNIKTLQ
KLPHILKELP ENFKVCPGIH TEALMVTLEM MCRSVMEFS
//
