ID H2PMT3_PONAB Unreviewed; 1590 AA.
AC H2PMT3; A0A2J8WJB0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=VWDE isoform 4 {ECO:0000313|EMBL:PNJ69861.1};
DE SubName: Full=von Willebrand factor D and EGF domains {ECO:0000313|Ensembl:ENSPPYP00000019926.2};
GN Name=VWDE {ECO:0000313|Ensembl:ENSPPYP00000019926.2};
GN ORFNames=CR201_G0009945 {ECO:0000313|EMBL:PNJ69861.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000019926.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000019926.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ69861.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ69861.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000019926.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; NDHI03003387; PNJ69861.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000020712.2; ENSPPYP00000019926.2; ENSPPYG00000017776.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160835; -.
DR HOGENOM; CLU_002130_1_0_1; -.
DR OMA; GNLCTCA; -.
DR OrthoDB; 2906846at2759; -.
DR TreeFam; TF351702; -.
DR Proteomes; UP000001595; Chromosome 7.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR14949:SF50; 3-PHYTASE; 1.
DR PANTHER; PTHR14949; EGF-LIKE-DOMAIN, MULTIPLE 7, 8; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1590
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158020"
FT DOMAIN 423..606
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1177..1216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1294..1326
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1358..1390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1391..1422
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1454..1486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1518..1550
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1268..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1206..1215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1298..1308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1316..1325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1362..1372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1380..1389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1394..1404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1412..1421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1458..1468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1476..1485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1522..1532
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1540..1549
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1590 AA; 177099 MW; 3370DD0204AC1D39 CRC64;
MPGGAWGLVI ALMFLARGEA QECSPGGHQF LRSPYRSVHL DSWHLQQSAV QDLICDHSLS
PGWYRFLIFD RPAEMPTKCV EMNHCGTQAP IWLSLRDSET LPSPGEIKQL TACATWQFLF
STTKDCCLFQ IPVSVRNCGN FFVYLLQPTQ GCMGYCAEAI SDARLHPCGS DETEIGGDCV
RQLTASLPPP PAGRPKVLVE LIESRLFCRC SFDVPPTKNS VGFYIAWSRL SSQEVKEELK
QETTVQAFSF LELDGINLRL GDRIFCSASV FFLENPHVQS VAIESQEFFA GIKLQPELST
ISEDGKEYYL RIESTVPIIC SEFSELDQEC KISLKLKTID QGREHLGLNL ALSSCHVDLL
QTSSCANGTC SHTFVYYTAV TDFSRDGDRV TNIVVQPIVN EDFLWNNYIP DSIQIKVKDV
PTAYCYSFTD PHIITFDGRV YDNFKTGTFV LYKSMSRDFE IHVRQWDCGS LHYPVSCNCG
FVAQEGGDVV TFDMCNGQLR ESQPYLFVKS QDVTRNIKIS ESYLGRKVTI WFSSGAFIRA
DLGEWGMSLT IRAPSVDYRN TLGLCGTFDE DPENDFHDKN GIQIGQNFNN YVAFINEWRI
LPGKSMFDTL PISMTSPGKP SYCSCSLDTA AYPSSDDLDS VSQSEIALGC KDLNHVSLSS
LIPELDVTSE YINSDTRVRE VNKRTSPEEY NLNLFPQEKK HINLTKLGLN VQKHPGNEKQ
EALQYLDNRK YTQGQGSHSQ EMRYNRENRW KRQNFYEFLP LFAFPSLSQT DLEELTYFFP
EDHAEDVQQE YFPSWPTPSG LTEYSTLTLC QQTLANSSIG RLCLAFLGKR VDSVIDICVK
DVLLKDDLSW AEAGVALLEN ECEKRIVEEG KYNTEEYGTS IEDILLVLKC PNLCSGNGQC
MEWGCVCFPN FSSYDCSDSY DKAPEIIELG NAGFCDVQKY NCMMVRVFGK GFKELPSIKC
EVTKLQYNSS EWMPGEPIYT QTLFQNSRAV DCQLPTDVQQ FDTMDLVGGK PTGKWQLKVS
NDGYKFSNPK IMVIYDGACQ VCGLYKNDSC TIKENVCIID GLCYVEGDKN PTSPCLICRP
KTSRFTWSFS ENNQPPVIQA LQDKLQTFYG ENFEYQFVAF DPEGSDIHFM LDSGPEGASV
SSAGLFMWKT DLLTPQQFTL RLNDDCNAET RVMIEVTVKS CDCLNGGSCV SDRNFSPGSG
VYLCVCLPGF HGSLCEVDIS GCQSNPCGLG SCVSGFHSYS CDCPPELKVE TQFLNKFTTQ
TVVLTRSDKS VNKEEDDKNA QGRKRHVKPT SGDAFTICKY PCGKSRECVA PNICKCKPGY
IGSNCQTALC DPDCKNHGKC IKPNICQCLP GHGGATCDEE HCNPPCQHGG TCLAGNLCTC
PYGFVGPRCE TMVCNRHCEN GGQCLTPDIC QCKPGWYGPT CSTALCDPVC LNGGSCNKPN
TCLCPNGFFG EHCQNAFCHP PCKNGGHCMR NNVCVCREGY TGRRCQKSIC DPMCMNGGKC
VGPSICSCPS GWSGKRCNTP VCLQKCKNGG ECIAPSICHC PSSWEGVRCQ IPICNPKCLY
GGRCIFPNVC SCRTEYSGVK CEKKIQIRHH
//
