ID H2PN21_PONAB Unreviewed; 1120 AA.
AC H2PN21; A0A2J8VLE3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=MAGI2 isoform 7 {ECO:0000313|EMBL:PNJ58340.1};
DE SubName: Full=Membrane associated guanylate kinase, WW and PDZ domain containing 2 {ECO:0000313|Ensembl:ENSPPYP00000020021.3};
GN Name=MAGI2 {ECO:0000313|Ensembl:ENSPPYP00000020021.3};
GN ORFNames=CR201_G0018119 {ECO:0000313|EMBL:PNJ58340.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000020021.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000020021.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ58340.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ58340.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000020021.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NDHI03003417; PNJ58340.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000020811.3; ENSPPYP00000020021.3; ENSPPYG00000017865.3.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000155057; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR TreeFam; TF316816; -.
DR Proteomes; UP000001595; Chromosome 7.
DR CDD; cd00992; PDZ_signaling; 5.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 5.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF27; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF00595; PDZ; 5.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 5.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50106; PDZ; 5.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 139..172
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 185..218
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 263..332
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 442..505
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 615..697
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 757..847
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 984..1066
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..894
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1120 AA; 123747 MW; AD86480269AD603F CRC64;
MELEKSGALL ESGTYEDNYY GTPKPPAEPA PLLLNVTDQI LPGATPSAEG KRKRNKSVSN
MEKASIEPPE EEEEERPVVN GNGVVVTPES SEHEDKSAGA SGEMPSQPYP APVYSQPEEL
KEQMDDTKPT KPEDNEEPDP LPDNWEMAYT EKGEVYFIDH NTKTTSWLDP RLAKKAKPPE
ECKENELPYG WEKIDDPIYG TYYVDHINRR TQFENPVLEA KRKLQQHNMP HTELGTKPLQ
APGFREKPLF TRDASQLKGT FLSTTLKKSN MGFGFTIIGG DEPDEFLQVK SVIPDGPAAQ
DGKMETGDVI VYINEVCVLG HTHADVVKLF QSVPIGQSVN LVLCRGYPLP FDPEDPANSM
VPPLAIMERP PPVMVNGRHN YETYLEYISR TSQSVPDITD RPPHTLHSMP ADGQLDGTYP
PPVHDDNVSM ASSGATQAEL MTLTIVKGAQ GFGFTIADSP TGQRVKQILD IQGCPGLCEG
DLIVEINQQN VQNLSHTEVV DILKDCPIGS ETSLIIHRGG FFSPWKTPKP IMDRWENQGS
PQTSLSAPAI PQNLPFPPAL HRSSFPDSTE AFDPRKPDPY ELYEKSRAIY ESRQQVPPRT
SFRMDSSGPD YKELDVHLRR MESGFGFRIL GGDEPGQPIL IGAVIAMGSA DRDGRLHPGD
ELVYVDGIPV AGKTHRYVID LMHHAARNGQ VNLTVRRKVL CGGEPCPENG RSPGSVSTHH
SSPRSDYATY TNSNHAAPSS NASPPEGFAS HSLQTSDVVI HRKENEGFGF VIISSLNRPE
SGSTITVPHK IGRIIDGSPA DRCAKLKVGD RILAVNGQSI INMPHADIVK LIKDAGLSVT
LRIIPQEELN SPTSAPSSEK QSPMAQQSPL AQQSPLAQPS PATPNSPIAQ PAPPQPLQLQ
GHENSYRSEV KARQDVKPDI RQPPFTDYRQ PPLDYRQPPG GDYQQPPPLD YRQPPLLDYR
QHSPDTRQYP LSDYRQPQDF DYFTVDMEKG AKGFGFSIRG GREYKMDLYV LRLAEDGPAI
RNGRMRVGDQ IIEINGESTR DMTHARAIEL IKSGGRRVRL LLKRGTGQVP EYGMVPSSLS
MCMKSDKHGS PYFYLLGHPK DTTNPPPGVL PLPPPQVCRK
//
