ID   H2PNI2_PONAB            Unreviewed;       442 AA.
AC   H2PNI2; A0A2J8U4C3; A0A663DH49;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Kelch domain-containing protein 10 {ECO:0000256|ARBA:ARBA00041041};
GN   Name=KLHDC10 {ECO:0000313|Ensembl:ENSPPYP00000020195.2};
GN   ORFNames=CR201_G0030350 {ECO:0000313|EMBL:PNJ40126.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000020195.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000020195.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ40126.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ40126.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000020195.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the KLHDC10 family.
CC       {ECO:0000256|ARBA:ARBA00038487}.
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DR   EMBL; NDHI03003470; PNJ40126.1; -; Genomic_DNA.
DR   RefSeq; XP_002818490.1; XM_002818444.1.
DR   STRING; 9601.ENSPPYP00000020195; -.
DR   Ensembl; ENSPPYT00000020988.3; ENSPPYP00000020195.2; ENSPPYG00000017999.3.
DR   GeneID; 100456843; -.
DR   KEGG; pon:100456843; -.
DR   CTD; 23008; -.
DR   eggNOG; KOG0379; Eukaryota.
DR   GeneTree; ENSGT00940000155977; -.
DR   HOGENOM; CLU_030914_0_0_1; -.
DR   OMA; IHKHYLY; -.
DR   OrthoDB; 2882436at2759; -.
DR   TreeFam; TF314081; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:Ensembl.
DR   GO; GO:0140627; P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; IEA:Ensembl.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46428; KELCH DOMAIN-CONTAINING PROTEIN 10; 1.
DR   PANTHER; PTHR46428:SF1; KELCH DOMAIN-CONTAINING PROTEIN 10; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF13418; Kelch_4; 1.
DR   Pfam; PF13854; Kelch_5; 1.
DR   Pfam; PF13964; Kelch_6; 1.
DR   SMART; SM00612; Kelch; 2.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
PE   3: Inferred from homology;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  49098 MW;  8D8AF4A6302A7A86 CRC64;
     MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG RPHLPGKKKI
     RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD NTNLYVFGGY NPDYDESGGP
     DNEDYPLFRE LWRYHFATGV WHQMGTDGYM PRELASMSLV LHGNNLLVFG GTGIPFGESN
     GNDVHVCNVK YKRWALLSCR GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN
     TREWTQLKPN NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE
     EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT FQWVKLPATM
     PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL VVPSLLELAW EKLLAAFPNL
     ANLSRTQLLH LGLTQGLIER LK
//