ID H2PUT6_PONAB Unreviewed; 598 AA.
AC H2PUT6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Arylsulfatase D {ECO:0000313|Ensembl:ENSPPYP00000022473.2};
GN Name=ARSD {ECO:0000313|Ensembl:ENSPPYP00000022473.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000022473.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000022473.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR RefSeq; XP_009232841.1; XM_009234566.1.
DR AlphaFoldDB; H2PUT6; -.
DR Ensembl; ENSPPYT00000023430.3; ENSPPYP00000022473.2; ENSPPYG00000020093.3.
DR GeneID; 100431750; -.
DR KEGG; pon:100431750; -.
DR CTD; 414; -.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00940000161140; -.
DR HOGENOM; CLU_006332_13_4_1; -.
DR InParanoid; H2PUT6; -.
DR OMA; KLFNLRM; -.
DR OrthoDB; 2913702at2759; -.
DR TreeFam; TF314186; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 1.10.287.550; Helix hairpin bin; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693:SF12; ARYLSULFATASE D; 1.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR Pfam; PF14707; Sulfatase_C; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..598
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003568275"
FT TRANSMEM 229..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..426
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 598 AA; 65328 MW; 6EEAAE31CA8A03C6 CRC64;
MRSAARRGLA APAARDSLPV LLFLCLLLKT CEPKTANAFK PNILLIMADD LGIGDLSCYG
NNTLRTPNID QLAEEGVRLT QHLAAAPLCT PSRAAFLTGR HSFRSGMDAS NGYRALQWNA
GSGGLPENET TFARILQQHG YATGLIGKWH QGVNCASRGD HCHHPLNHGF DYFYGMPFTL
TNDCDPGRPP EVDAALRAQL WGYTQFLALG ILSVAAGQTC GFISVSARAV TGMAGVGFLF
FISWYSSFGF VRRWNCILMR NHDVTEQPMV LEKTASLMLK EAVSYIERHK HGPFLLFLSL
LHVHIPLVTT SAFLGKSQHG LYGDNVEEMD WLVGKVLNAI EDNGLKNSTF TYFTSDHGGH
LEARDGHSQL GGWNGIYKGG KGMGGWEGGI RVPGIFRWPG VLPAGRVIGE PTSLMDVFPT
VVQLAGGEVP QDRVIDGHSL VPLLQGAEAR SAHEFLFHYC GQHLHAARWH QKDSGSVWKV
HYTTPQFHPE GAGACYGRGI CPCSGEGVTH HRPPLLFDLS RDPSEARPLT PDSEPLYHAV
IARVGAAVSE HRQTLSPVPQ QFSTSNILWK PWLQPCCGHF PFCSCHEDGD GTPQMPGL
//
