ID H2Q1X7_PANTR Unreviewed; 932 AA.
AC H2Q1X7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=BicC family RNA binding protein 1 {ECO:0000313|Ensembl:ENSPTRP00000004340.5};
GN Name=BICC1 {ECO:0000313|Ensembl:ENSPTRP00000004340.5,
GN ECO:0000313|VGNC:VGNC:11669};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000004340.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000004340.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000004340.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BicC family.
CC {ECO:0000256|ARBA:ARBA00007662}.
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DR EMBL; AACZ04022683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04022684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Q1X7; -.
DR Ensembl; ENSPTRT00000004710.5; ENSPTRP00000004340.5; ENSPTRG00000002520.5.
DR VGNC; VGNC:11669; BICC1.
DR eggNOG; KOG2208; Eukaryota.
DR eggNOG; KOG4374; Eukaryota.
DR GeneTree; ENSGT00940000156276; -.
DR HOGENOM; CLU_008040_0_0_1; -.
DR OMA; PDNDTPY; -.
DR TreeFam; TF323767; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002520; Expressed in fibroblast and 19 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22421; KH-I_BICC1_rpt2; 1.
DR CDD; cd22422; KH-I_BICC1_rpt3; 1.
DR CDD; cd09520; SAM_BICC1; 1.
DR Gene3D; 3.30.310.270; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR047554; BICC1_KH-I_rpt2.
DR InterPro; IPR047553; BICC1_KH-I_rpt3.
DR InterPro; IPR037974; BICC1_SAM_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR10627:SF78; PROTEIN BICAUDAL C HOMOLOG 1; 1.
DR PANTHER; PTHR10627; SCP160; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 831..894
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 551..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 100554 MW; E319250FBA0DC099 CRC64;
CRDGVSLYCP GWSQIPGLKQ SSCLSLPNQY FSQFLLQIME ETNTQIAWPS KLKIGAKSKK
DPHIKVSGKK EDVKEAKEMI MSVLDTKSNR VTLKMDVSHT EHSHVIGKGG NNIKKVMEET
GCHIHFPDSN RNNQAEKSNQ VSIAGQPAGV ESARVRIREL LPLVLMFELP IAGILQPVPD
PNSPSIQHIS QTYNISVSFK QRSRMYGATV IVRGSQNNTS AVKEGTAMLL EHLAGSLASA
IPVSTQLDIA AQHHLFMMGR NGSNIKHIMQ RTGAQIHFPD PSNPQKKSTV YLQGTIESVC
LARQYLMGCL PLVLMFDMKE EIEVDPQFIA QLMEQLDVFI SIKPKPKQPS KSVIVKSVER
NALNMYEARK CLLGLESSGV TIATSPSPAS CPAGLACPSL DILASAGLGL TGLGLLGPTT
LSLNTSTTPN SLLNALNSSV SPLQSPSSGT PSPTLWAPPL ANTSSATGFS AIPHLMIPST
AQATLTNILL SGVPTYGHTA PSPPPGLTPV DVHINSMQTE GKKISAALNG HAQSPNIKYG
AISTSSLGEK VLSANHGDPS IQTSGSEQTS PKSSPTEGCN DAFVEVGMPR SPSHSGNAGD
LKQMMCPSKV SCAKRQTVEL LQGTKNSHLH STDRLLSDPE LSATESPLAD KKAPGSERAA
ERAAAAQQNS ERAHLAPRSS YVNMQAFDYE QKKLLATKAM LKKPVVTEVR TPTNTWSGLG
FSKSMPAETI KELRRANHVS YKPTMTTTYE GSSMSLSRSN SREHLGSGSE SDNWRDRNGI
GPGSHSEFAA SIGSPKRKQN KSTEHYLSSS NYMDCISSLT GSNGCNLNSS FKGSDLPELF
SKLGLGKYTD VFQQQEIDLQ TFLTLTDQDL KELGITTFGA RRKMLLAISE LNKNRRKLFE
SPNARTSFLE GGASGRLPRQ YHSDIASVSG RW
//
