ID H2Q3E4_PANTR Unreviewed; 1025 AA.
AC H2Q3E4; A0A2J8P3X3; K7CA85;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Ankyrin repeat and BTB (POZ) domain containing 2 {ECO:0000313|EMBL:JAA15812.1};
DE SubName: Full=Ankyrin repeat and BTB domain containing 2 {ECO:0000313|Ensembl:ENSPTRP00000006071.4};
GN Name=ABTB2 {ECO:0000313|EMBL:JAA15812.1,
GN ECO:0000313|Ensembl:ENSPTRP00000006071.4, ECO:0000313|VGNC:VGNC:7644};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000006071.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000006071.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA15812.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Smooth vascular {ECO:0000313|EMBL:JAA15812.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000006071.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04016457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01006333; JAA15812.1; -; mRNA.
DR STRING; 9598.ENSPTRP00000006071; -.
DR PaxDb; 9598-ENSPTRP00000006071; -.
DR Ensembl; ENSPTRT00000006584.4; ENSPTRP00000006071.4; ENSPTRG00000003495.4.
DR VGNC; VGNC:7644; ABTB2.
DR eggNOG; ENOG502QSQY; Eukaryota.
DR GeneTree; ENSGT00940000157661; -.
DR HOGENOM; CLU_001918_0_0_1; -.
DR OMA; LQCNGST; -.
DR TreeFam; TF106437; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000003495; Expressed in adult mammalian kidney and 20 other cell types or tissues.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0097237; P:cellular response to toxic substance; IEA:Ensembl.
DR CDD; cd18526; BACK_ABTB2; 1.
DR CDD; cd18350; BTB_POZ_ABTB2_BPOZ2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR048063; ABTB2_BTB_POZ.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46071; ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR46071:SF3; ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47113; Histone-fold; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT REPEAT 521..553
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 567..599
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 606..632
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 845..914
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 1025 AA; 113543 MW; 8B5B9701F6F30A2F CRC64;
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF
SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
EIRARVMASQ SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR
AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH
GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA
MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIKEEEYN
EELVTEGLQL MFDILKTSKN DSVIQQLAAI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN
NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI CDMKYHIFQM
MMQYLYYGGT ESMEIPTADI LELLSAASLF QLDALQRHCE ILCSQTLSVE SAVNTYKYAK
IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY
ITSRV
//
