ID H2QDH7_PANTR Unreviewed; 452 AA.
AC H2QDH7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Carboxypeptidase {ECO:0000256|RuleBase:RU361156};
DE EC=3.4.16.- {ECO:0000256|RuleBase:RU361156};
GN Name=SCPEP1 {ECO:0000313|Ensembl:ENSPTRP00000016023.5,
GN ECO:0000313|VGNC:VGNC:12668};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000016023.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000016023.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000016023.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S10 family.
CC {ECO:0000256|ARBA:ARBA00009431, ECO:0000256|RuleBase:RU361156}.
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DR EMBL; AACZ04026981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001172174.1; XM_001172174.4.
DR AlphaFoldDB; H2QDH7; -.
DR MEROPS; S10.013; -.
DR PaxDb; 9598-ENSPTRP00000016023; -.
DR Ensembl; ENSPTRT00000017306.6; ENSPTRP00000016023.5; ENSPTRG00000009434.7.
DR GeneID; 455148; -.
DR KEGG; ptr:455148; -.
DR CTD; 59342; -.
DR VGNC; VGNC:12668; SCPEP1.
DR eggNOG; KOG1283; Eukaryota.
DR GeneTree; ENSGT00940000156193; -.
DR HOGENOM; CLU_008523_1_0_1; -.
DR InParanoid; H2QDH7; -.
DR OMA; LEAENTW; -.
DR OrthoDB; 1647009at2759; -.
DR TreeFam; TF313740; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009434; Expressed in heart and 21 other cell types or tissues.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:Ensembl.
DR GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802:SF3; RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR11802; SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|RuleBase:RU361156};
KW Hydrolase {ECO:0000256|RuleBase:RU361156};
KW Protease {ECO:0000256|RuleBase:RU361156};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|RuleBase:RU361156}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|RuleBase:RU361156"
FT CHAIN 27..452
FT /note="Carboxypeptidase"
FT /evidence="ECO:0000256|RuleBase:RU361156"
FT /id="PRO_5006525481"
SQ SEQUENCE 452 AA; 50785 MW; A6CF64821F3A0466 CRC64;
MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVMVRKDAY MFWWLYYATN
SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP RKTTWLQAAS LLFVDNPVGT
GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF NCHKEFQTVP FYIFSESYGG KMAAGIGLEL
YKAIQRGTIK CNFAGVALGD SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA
VNKGLYREAT ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH
VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQAANVFVN MAEDFMKPVI SIVDELLEAG
INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK ALYSDPKSLE TSAFVKSYKN
LAFYWILKAG HMVPSDQGNM ALKMMRLVTQ QD
//
