ID   H2QI03_PANTR            Unreviewed;       753 AA.
AC   H2QI03;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN   Name=PPP3R1 {ECO:0000313|Ensembl:ENSPTRP00000020605.6};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000020605.6, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000020605.6, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000020605.6}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcineurin regulatory subunit family.
CC       {ECO:0000256|ARBA:ARBA00023774}.
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DR   EMBL; AACZ04063552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2QI03; -.
DR   PaxDb; 9598-ENSPTRP00000020605; -.
DR   Ensembl; ENSPTRT00000022328.6; ENSPTRP00000020605.6; ENSPTRG00000041941.2.
DR   eggNOG; ENOG502QRKB; Eukaryota.
DR   GeneTree; ENSGT00950000183091; -.
DR   HOGENOM; CLU_062543_0_0_1; -.
DR   InParanoid; H2QI03; -.
DR   TreeFam; TF351064; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   Bgee; ENSPTRG00000041941; Expressed in Brodmann (1909) area 10 and 21 other cell types or tissues.
DR   GO; GO:0005955; C:calcineurin complex; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0019902; F:phosphatase binding; IBA:GO_Central.
DR   GO; GO:0097720; P:calcineurin-mediated signaling; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR015757; Calcineur_B.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR45942:SF3; CALCINEURIN SUBUNIT B TYPE 1; 1.
DR   PANTHER; PTHR45942; PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1; 1.
DR   Pfam; PF13499; EF-hand_7; 2.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00054; EFh; 4.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          104..139
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          141..176
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          182..217
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REPEAT          528..541
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   753 AA;  83182 MW;  34E03C529516057D CRC64;
     MSNTIATRYM GLRVLHRGDS SPDGPCNSVV DPSRYTDAQI PLTASRRTWI FPVFLDLGTF
     LKNSCFLFFD ADEIKRLGKR FKKLDLDNSG SLSVEEFMSL PELQQNPLVQ RVIDIFDTDG
     NGEVDFKEFI EGVSQFSVKG DKEQKLRFAF RIYDMDKDGY ISNGELFQVL KMMVGNNLKD
     TQLQQIVDKT IINADKDGDG RISFEEFCAR GGKTGLFAGL ASSVSMRPAS PPSPAADSCS
     ACRFFARRPP LRVTWVKPSS APALCASISD SIPGNLKALP AETRAQLHHA EASLSQPPLQ
     LRPFPKTSQA GDLQDLGPGY VCVRKAVGKG DKQIRAVVKE HSVRSQERIW HYPGITTANM
     PGHLGQNTES GRDKLPMLPF LGALGVAVAV AEIGCTMSAF EKPQIIAHIQ KGFNYTVFDC
     KWVPCSAKFV TMGNFARGTG VIQLYEIQHG DLKLLREIEK AKPIKCGTFG ATSLQQRYLA
     TGDFGGNLHI WNLEAPEMPV YSVKGHKEII NAIDGVGGLG IGEGAPEIVT GSRDGTVKVW
     DPRQKDDPVA NMEPVQGENK RDCWTVAFGN AYNQEERVVC AGYDNGDIKL FDLRNMALRW
     ETNIKNGVCS LEFDRKDISM NKLVATSLEG KFHVFDMRTQ HPTKGFASVS EKAHKSTVWQ
     VRHLPQNREL FLTAGGAGGL HLWKYEYPIQ RSKKDSEGIE MGVAGSVSLL QNVTLSTQPI
     SSLDWSPDKR GLCVCSSFDQ TVRVLIITKL NKI
//