ID H2QKW2_PANTR Unreviewed; 214 AA.
AC H2QKW2; A0A2J8MQ60;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=N-6 adenine-specific DNA methyltransferase 1 {ECO:0000313|EMBL:JAA06549.1, ECO:0000313|Ensembl:ENSPTRP00000023802.4};
GN Name=N6AMT1 {ECO:0000313|EMBL:JAA06549.1,
GN ECO:0000313|Ensembl:ENSPTRP00000023802.4,
GN ECO:0000313|VGNC:VGNC:10504};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000023802.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000023802.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000023802.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136134; DOI=10.1038/nature04101;
RA Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T., Rozen S.,
RA Wilson R.K., Page D.C.;
RT "Conservation of Y-linked genes during human evolution revealed by
RT comparative sequencing in chimpanzee.";
RL Nature 437:100-103(2005).
RN [3] {ECO:0000313|EMBL:JAA06549.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA06549.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA33346.1}, Skin {ECO:0000313|EMBL:JAA23901.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA11779.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSPTRP00000023802.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal PrmC-related family.
CC {ECO:0000256|ARBA:ARBA00006149}.
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DR EMBL; AACZ04064261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04064262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01004789; JAA06549.1; -; mRNA.
DR EMBL; GABF01010366; JAA11779.1; -; mRNA.
DR EMBL; GABD01009199; JAA23901.1; -; mRNA.
DR EMBL; GABE01011393; JAA33346.1; -; mRNA.
DR RefSeq; XP_525443.2; XM_525443.6.
DR STRING; 9598.ENSPTRP00000087065; -.
DR PaxDb; 9598-ENSPTRP00000023802; -.
DR Ensembl; ENSPTRT00000025788.5; ENSPTRP00000023802.4; ENSPTRG00000013817.6.
DR GeneID; 470059; -.
DR CTD; 29104; -.
DR VGNC; VGNC:10504; N6AMT1.
DR eggNOG; KOG3191; Eukaryota.
DR GeneTree; ENSGT00390000013073; -.
DR HOGENOM; CLU_018398_6_0_1; -.
DR OMA; EWDDWME; -.
DR OrthoDB; 124743at2759; -.
DR TreeFam; TF314919; -.
DR Proteomes; UP000002277; Chromosome 21.
DR Bgee; ENSPTRG00000013817; Expressed in heart and 22 other cell types or tissues.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004557; PrmC-related.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00537; hemK_rel_arch; 1.
DR PANTHER; PTHR45875; METHYLTRANSFERASE N6AMT1; 1.
DR PANTHER; PTHR45875:SF3; METHYLTRANSFERASE N6AMT1; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:JAA06549.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:JAA06549.1}.
FT DOMAIN 29..126
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 214 AA; 23057 MW; 30031BC87E5EB538 CRC64;
MAGQSFATPF HGHVGRGAFS DVYEPAEDTF LLLDALEAAA AELARVEICL EVGSGSGVVS
AFLASMIGPQ ALYMCTDINP EAAACTLETA RCNKVHIQPV ITDLVKGLLP RLTEKVDLLV
FNPPYVVTPP QEVGSHGIEA AWAGGRNGRE VMDRFFPLVP DLLSPRGLFY LVTIKENNPE
EILKIMKTKG LQGTTALSRQ AGRETLSVLK FTKS
//
