ID H2QL13_PANTR Unreviewed; 174 AA.
AC H2QL13; A0A2J8M7Y5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Guided entry of tail-anchored proteins factor 1 {ECO:0000256|ARBA:ARBA00017951};
DE AltName: Full=Tail-anchored protein insertion receptor WRB {ECO:0000256|ARBA:ARBA00032437};
DE AltName: Full=Tryptophan-rich basic protein {ECO:0000256|ARBA:ARBA00033006};
GN Name=GET1 {ECO:0000313|Ensembl:ENSPTRP00000023947.4,
GN ECO:0000313|VGNC:VGNC:1112};
GN Synonyms=WRB {ECO:0000313|EMBL:JAA03983.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000023947.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000023947.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000023947.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136134; DOI=10.1038/nature04101;
RA Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T., Rozen S.,
RA Wilson R.K., Page D.C.;
RT "Conservation of Y-linked genes during human evolution revealed by
RT comparative sequencing in chimpanzee.";
RL Nature 437:100-103(2005).
RN [3] {ECO:0000313|EMBL:JAA03983.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03983.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA44281.1}, Skin {ECO:0000313|EMBL:JAA25607.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA20633.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSPTRP00000023947.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WRB/GET1 family.
CC {ECO:0000256|ARBA:ARBA00010799}.
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DR EMBL; AC157524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01007355; JAA03983.1; -; mRNA.
DR EMBL; GABF01001512; JAA20633.1; -; mRNA.
DR EMBL; GABD01007493; JAA25607.1; -; mRNA.
DR EMBL; GABE01000458; JAA44281.1; -; mRNA.
DR RefSeq; NP_001238848.1; NM_001251919.1.
DR PaxDb; 9598-ENSPTRP00000023947; -.
DR Ensembl; ENSPTRT00000025953.5; ENSPTRP00000023947.4; ENSPTRG00000013915.6.
DR GeneID; 100611690; -.
DR KEGG; ptr:100611690; -.
DR CTD; 7485; -.
DR VGNC; VGNC:1112; GET1.
DR eggNOG; KOG4253; Eukaryota.
DR GeneTree; ENSGT00390000008610; -.
DR HOGENOM; CLU_121992_0_0_1; -.
DR OMA; AEWIISF; -.
DR OrthoDB; 2917135at2759; -.
DR TreeFam; TF314708; -.
DR Proteomes; UP000002277; Chromosome 21.
DR Bgee; ENSPTRG00000013915; Expressed in Brodmann (1909) area 10 and 21 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043529; C:GET complex; IBA:GO_Central.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IBA:GO_Central.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR028945; Get1.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR PANTHER; PTHR42650:SF1; GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1; 1.
DR PANTHER; PTHR42650; TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB; 1.
DR Pfam; PF04420; CHD5; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 39..92
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 174 AA; 19780 MW; A01F11CC564EAB6E CRC64;
MSSAAADHWA WLLVLSFVFG CNVLRILLPS FSSFMSRVLQ KDAEQESQMR AEIQDMKQEL
STVNMMDEFA RYARLERKIN KMTDKLKTHV KARTAQLAKI KWVISVAFYV LQAALMISLI
WKYYSVPVAV VPSKWITPLD RLVAFPTRVA GGVGITCWIL VCNKVVAIVL HPFS
//
