ID H2QLG1_PANTR Unreviewed; 1020 AA.
AC H2QLG1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Neurofilament heavy chain {ECO:0000313|Ensembl:ENSPTRP00000024490.4};
GN Name=NEFH {ECO:0000313|Ensembl:ENSPTRP00000024490.4,
GN ECO:0000313|VGNC:VGNC:12904};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000024490.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000024490.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164055; DOI=10.1038/nature02564;
RA Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA Khaitovich P., Paabo S., Reinhardt R., Zheng H.-J., Zhang X.-L., Zhu G.-F.,
RA Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E.,
RA Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G.,
RA Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S., Wang S.-Y.,
RA Yaspo M.-L., Sakaki Y.;
RT "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL Nature 429:382-388(2004).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000024490.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000024490.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AACZ04068116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QLG1; -.
DR PaxDb; 9598-ENSPTRP00000024490; -.
DR Ensembl; ENSPTRT00000026573.4; ENSPTRP00000024490.4; ENSPTRG00000014224.6.
DR VGNC; VGNC:12904; NEFH.
DR eggNOG; ENOG502QYDU; Eukaryota.
DR GeneTree; ENSGT00940000161893; -.
DR HOGENOM; CLU_012560_7_2_1; -.
DR InParanoid; H2QLG1; -.
DR OMA; FHSWTRT; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000002277; Chromosome 22.
DR Bgee; ENSPTRG00000014224; Expressed in primary visual cortex and 12 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0097418; C:neurofibrillary tangle; IEA:Ensembl.
DR GO; GO:0005883; C:neurofilament; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0099184; F:structural constituent of postsynaptic intermediate filament cytoskeleton; IBA:GO_Central.
DR GO; GO:0061564; P:axon development; IBA:GO_Central.
DR GO; GO:0045110; P:intermediate filament bundle assembly; IBA:GO_Central.
DR GO; GO:0033693; P:neurofilament bundle assembly; IEA:Ensembl.
DR GO; GO:1902513; P:regulation of organelle transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR010790; DUF1388.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF07142; DUF1388; 2.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 97..413
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 58..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..135
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 178..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 297..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 58..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..498
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 111676 MW; C29F3EA41EB9528C CRC64;
MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGAGGTRSA AGSSSGFHSW TRTSVSSVSA
SPSRFRGAGA ASSTDSLDTL SNGPEGCMVA VATSRSEKEQ LQALNDRFAG YIDKVRQLEA
HNRSLEGEAA ALRQQQAGRS AMGELYEREV REMRGAVLRL GAARGQLRLE QEHLLEDIAH
VRQRLDDEAR QREEAEAAAR ALARFAQEAE AARVDLQKKA QALQEECGYL RRHHQEEVGE
LLGQIQGSGA AQAQMQAETR DALKCDVTSA LREIRAQLEG HAVQSTLQSE EWFRVRLDRL
SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKD SLERQRSELE DRHQADIASY
QEAIQQLDAE LRNTKWEMAA QLREYQDLLN VKMALDIEIA AYRKLLEGEE CRIGFGPIPF
SLPEGLPKIP SVSTHIKVKS EEKIKVVEKS EKETVIVEEQ TEETQVTEEV TEEEEKEAKE
EEGKEEEGGE EEEAEGGEEE TKSPPAEEAA SPEKEAKSPV KEEAKSPAEA KSPEKEEAKS
PAEVKSPEKA KSPAKEEAKS PPEAKSPEKE EAKSPVEVKS PEKAKSPAKE EAKSPAEAKS
PEKAKSPVKE EAKSPAEAKS PVKEEAKSPA EVKSPEKGKS PTKEEAKSPE KAKSPEKEEA
KSPEKAKSPV KAEAKSPEKA KSPVKAEAKS PEKAKSPVKA EAKSPEKAKS PVKAEAKSPE
KAKSPVKEEA KTPEKAKSPV KEEAKSPEKA KSPEKAKTLD VKSPEAKTPA KEEARSPADK
SPEKAKSPVK EEVKSPEKAK SPLKEDAKAP EKEIPKKEEV KSPVKEEEKP QEVKVKEPPK
KAEEEKAPAT PKTEEKKDSK KEEAPKKEAP KPKVEEKKEP AVEKPKESKV EAKKEEAEDK
KKVPTPEKEA PAKVEVKEDA KPKEKTEVAK KEPDDAKAKE PSKPAEKKEA APEKKDTKEE
KAKKPEEKPK TEAKAKEDDK TLSKEPSKPK AEKAEKSSST DQKDSKPPEK ATEDKAAKGK
//
