ID H2QPV8_PANTR Unreviewed; 1039 AA.
AC H2QPV8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 {ECO:0000313|Ensembl:ENSPTRP00000027952.4};
GN Name=HERC6 {ECO:0000313|Ensembl:ENSPTRP00000027952.4,
GN ECO:0000313|VGNC:VGNC:48902};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000027952.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000027952.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000027952.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04021329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2QPV8; -.
DR PaxDb; 9598-ENSPTRP00000027952; -.
DR Ensembl; ENSPTRT00000030282.4; ENSPTRP00000027952.4; ENSPTRG00000016272.7.
DR VGNC; VGNC:48902; HERC6.
DR eggNOG; KOG0941; Eukaryota.
DR GeneTree; ENSGT00940000162279; -.
DR HOGENOM; CLU_002173_5_3_1; -.
DR InParanoid; H2QPV8; -.
DR TreeFam; TF315189; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016272; Expressed in heart and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF11; E3 UBIQUITIN-PROTEIN LIGASE HERC6-RELATED; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 3.
DR Pfam; PF13540; RCC1_2; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 42..93
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 94..146
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 147..199
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 200..254
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 255..305
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 712..1033
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 1004
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1039 AA; 116970 MW; DBB66780F5C7CE74 CRC64;
MYFCWGTDSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA
QRGELPEPIQ ALETLTVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPK
KITTLNGIKI IQVSCGHYHS LALSKDSQVF SWGKNSHGQL GLGKEFPSQA SPQRVRSLEG
IPLAQVAAGG AHSFALSLCG TSFGWGSNSS GQLALSGRNV PVQSNKPLSV GALKNLGVVY
ISCGDAHTAV LTQDGKVFTF GDNRSGQLGY SPTPEKRGPQ LVERIDGLVS QIDCGSYHTL
AYVHTTGQVV SFGHGPSDTS KPTHSEALTE NFDISCLISA EDLVDVHVKH IFAGTYANFV
TTHQDTSSTR APGKTLPEIS RISQSMAEKW IAVKRRSTEH EMAKSEIRMI FSSPACLTAS
FLKKRGTGET TSIDVDLEMA RDTFKNEILN FTACFSQSSV SNISWVCSLI LFLPQITTCL
EDDLLRALPC RSPHQEALSV FLLLPECPVM HDSKNWKNLV VPFAKAVCEM SKQSLQVLKK
CWAFLQESSL NPLIQMLKAA IISQLLHWTE TEQCHCNVKA LLGMMKELHK VNKANCRLPE
NTFNINELSN LLNFYIDRRR QFFRDNHLIP AETPSPVIFS DFPFIFNLLS KIKLLQADSL
IKMQMSENKA YMPMHETILQ KKDEFPPSPR FILKVRRSRL VKDALRQLSQ AEATDFCKVL
VVEFINEICP ESGGVSSEFF HCMFEEMTKP EYGMFMYPEM GSCMWFPAKP KPEKKRYFLF
GILCGLSLFN LNVANLPFPL ALYKKLLDQK PSLEDLKELS PRLGKSLQEV LDDDADDIGD
ALCIRFSIHW DQNDVDLIPN GISIPVDQTN KRDYVSKYID YIFNVSVKAV YEEFQRGFYT
VCEKEILRHF YPEELMTAII GNTDYDWKQF EQNSKYEQGY QKSHPTIQLF WKAFHKLTLD
EKKKFLFFLT GRDRLHARGI QKMEIVFCCP ETFSERDHPT SLTCHNILYL PKYSTMERME
EALQVAINNN RGFVSPMLT
//
